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PHR1789

Supelco

Doxorubicine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

DOX, Hydroxydaunorubicine hydrochloride

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About This Item

Formule empirique (notation de Hill):
C27H29NO11 · HCl
Numéro CAS:
25316-40-9
Poids moléculaire :
579.98
Beilstein:
4229251
Numéro CE :
246-818-3
Numéro MDL:
MFCD00077757
Code UNSPSC :
41116107
ID de substance PubChem :
329823614
Nomenclature NACRES :
NA.24
Le tarif et la disponibilité ne sont pas disponibles actuellement.

Qualité

certified reference material
pharmaceutical secondary standard

Niveau de qualité

300

Agence

traceable to BP 990
traceable to Ph. Eur. D2975000
traceable to USP 1225703

Famille d'API

doxorubicin

Forme

powder

CofA (certificat d'analyse)

current certificate can be downloaded

Conditionnement

pkg of 200 mg

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Pf

216 °C (dec.) (lit.)

Application(s)

pharmaceutical (small molecule)

Température de stockage

-10 to -25°C

Chaîne SMILES 

Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO

InChI

1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1

Clé InChI

MWWSFMDVAYGXBV-RUELKSSGSA-N

Informations sur le gène

human ... TOP2A(7153)

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Catégories apparentées

Description générale

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Doxorubicin Hydrochloride is an anthracycline antibiotic, known for its broad range anti-cancer activities.

Application

This pharmaceutical secondary standard can also be used as follows:
  • Development of a reversed-phase high-performance liquid chromatographic (RP-HPLC) method combined with UV detection to determine doxorubicin hydrochloride in plasma samples[1]
  • Electrochemical determination of doxorubicin by spinel-structured cobalt ferrite (CoFe2O4) modified carbon paste electrode in biological fluid and injection samples[2]
  • Determination of doxorubicin hydrochloride in human plasma samples using a graphene quantum dots (GQDs) based electrochemical sensor
  • RP-HPLC method-based quantitative analysis of doxorubicin hydrochloride in vacuum foam dried formulations[3]
  • Voltammetric determination of doxorubicin hydrochloride and dastinib using zinc oxide (ZnO) nanoparticle/1-butyl-3-methylimidazolium tetra-fluoroborate modified carbon paste electrode (ZnO-NPs/BMTFB/CPE) in their combined injection samples[4]

Remarque sur l'analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Note de bas de page

To see an example of a Certificate of Analysis for this material enter LRAB3692 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Produits recommandés

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Danger

Mentions de danger

H302,H340,H350,H360FD

Classification des risques

Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

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Sigma-Aldrich

D8809

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Sigma-Aldrich

D7000

Deoxycorticosterone acetate

Dox-NP™ (2mL vial) Avanti Research™ - A Croda Brand

Avanti

300112S

Dox-NP™ (2mL vial)

Fast and sensitive determination of doxorubicin using multi-walled carbon nanotubes as a sensor and CoFe2O4 magnetic nanoparticles as a mediator
Taei M, et al.
Microchimica Acta, 183, 49-56 (2016)
A simple HPLC bioanalytical method for the determination of doxorubicin hydrochloride in rat plasma: application to pharmacokinetic studies
Dharmalingam SR, et al.
Tropical Journal of Pharmaceutical Research, 13, 409-415 (2014)
Simultaneous determination of doxorubicin and dasatinib as two breast anticancer drugs uses an amplified sensor with ionic liquid and ZnO nanoparticle
Alavi-Tabari SAR, et al.
Journal of Electroanalytical Chemistry, 811, 84-88 (2018)
Development and validation of RP-HPLC method for determination of doxorubicin hydrochloride from vacuum foam dried formulation
Hajare AA, et al.
Research Journal of Pharmacy and Technology, 9, 1352-1356 (2016)
Yi-Fang Yang et al.
The Kaohsiung journal of medical sciences, 35(7), 408-416 (2019-04-20)
Breast cancer is the most common female-specific malignancy in Taiwan and developed countries worldwide, and its incidence continues to grow. 14-3-3ε (YWHAE), which belong to 14-3-3 family, it has been reported up-regulated in breast cancer tissues. However, the clinical implication
Afficher tous les articles scientifiques apparentés

Questions

  1. How should the doxorubicin be dissolved? I have seen DMSO, but what is the optimal solution to dilute the DMSO and at what percentage?

    1 answer

    1. This product is not tested for solubility. However, information available for other Doxorubicin HCl products will apply.
      D1515, Doxorubicin HCl, is soluble in water and pure DMSO at 50 mg/ml.
      Solutions are sensitive to light and will degrade over long-term exposure.
      https://www.sigmaaldrich.com/product/sigma/d1515

      D5225, Doxorubicin, Ready-Made solution is a 2mg/ml solution in pure DMSO.
      The product is stored at 20°C and is assigned a retest schedule of every 2 years.
      https://www.sigmaaldrich.com/product/sigma/d5220

      Solutions appear to be reasonably stable when protected from light.
      See the link below to review a publication regarding the solution stability of Doxorubicin HCl.:
      https://pubmed.ncbi.nlm.nih.gov/517541/

      Helpful?

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