654255

TNF-α Antagonist

≥95% (HPLC), lyophilized, TNF-α antagonist, Calbiochem^®

• Synonyme(s) : TNF-α Antagonist, TNF Antagonist, WP9QY, Tumor Necrosis Factor Antagonist, TNF-TNFR Signaling Inhibitor I
• Formule empirique (notation de Hill): C₅₈H₇₁N₁₁O₁₅S₂
• Poids moléculaire : 1226.38
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• product name: TNF-α Antagonist, The TNF-α Antagonist controls the biological activity of TNF-α.
• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: lyophilized
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Solubilité: water: 1 mg/mL; 5% acetic acid: 5 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C

Description

Description générale

An exocyclic peptidomimetic that acts as a TNF-α antagonist (IC₅₀ = 5 µM) in binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. Exhibits about twofold higher activity than other known WP5 binding site derived mimetics. Designation WP9QY arises from the binding to the WP9 binding site of the TNF-β/TNF-receptor(I) complex as template, and the introduction of amino acids, Gln and Tyr.

An exocyclic peptidomimetic that acts as a TNF-α antagonist (IC₅₀ = 5 µM) in the binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. The designation WP9QY arises from the binding to the site observed in the TNF-β/TNF-receptor (I) complex as template, and the introduction of amino acids Glu and Tyr.

Actions biochimiques/physiologiques

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 5 µM as TNF-α antagonist

Avertissement

Toxicity: Standard Handling (A)

Séquence

H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH (disulfide bond: 2 → 8)

Autres remarques

Takasaki, W., et al. 1997. Nat. Biotechnol. 15, 1266.

Informations légales

Sold under license of U.S. Patent 6,265,535.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable