454126

Methotrexate

≥98% (HPLC), solid, thymidylate synthetase inhibitor, Calbiochem^®

• Synonyme(s) : Methotrexate
• Formule empirique (notation de Hill): C₂₀H₂₂N₈O₅ · 3H₂O
• Numéro CAS: 59-05-2
• Poids moléculaire : 508.49
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• product name: Methotrexate,
• Pureté: ≥98% (HPLC)
• Niveau de qualité: 100
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: yellow
• Solubilité: DMSO: 100 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
• Clé InChI: FBOZXECLQNJBKD-ZDUSSCGKSA-N

Description

Description générale

Inhibits thymidylate synthetase, is a nonselective de novo purine synthesis inhibitor and has a significant toxicity profile including hepatotoxicity, pneumonitis and bone marrow suppression. Potent folic acid antagonist. Induces apoptosis in HL-60 human leukemia cells. Also useful as an anti-tumor agent.

Avertissement

Toxicity: Toxic (F)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Kaufman, S.H., et al. 1993. Cancer Res.53, 3976.
Takasuga, A., et al. 1992. J. Biochem.112, 652.
Hirata, S., et al. 1989. Arthritis Rheum. 32, 1065.
Jolivet, J., et al. 1983. New Engl. J. Med. 309, 1094.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H301,H341,H360D,H372
• Conseils de prudence: P202 - P260 - P264 - P280 - P301 + P310 - P405
• Classification des risques: Acute Tox. 3 Oral - Muta. 2 - Repr. 1B - STOT RE 1
• Organes cibles: Liver,Bone marrow
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable