900831

3-(3-(But-3-yn-1-yl)-3H-diazirin-3-yl)propanoic acid

• Synonyme(s) : Carboxyl diazirine alkyne, Probe building block
• Formule empirique (notation de Hill): C₈H₁₀N₂O₂
• Numéro CAS: 1450754-37-6
• Poids moléculaire : 166.18
• Numéro MDL: MFCD31433997
• Code UNSPSC : 12352106

Propriétés

• Forme: liquid
• Niveau de qualité: 100
• Capacité de réaction: reaction type: click chemistry
• Disponibilité: available only in USA
• Température de stockage: −20°C
• Chaîne SMILES: C#CCCC1(N=N1)CCC(O)=O

Description

Application

Used for chemical probe synthesis, this trifunctional building block contains a light-activated diazirine, alkyne tag, and carboxylic acid synthetic handle. When appended to a ligand or pharmacophore through its acid linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Autres remarques

Design and Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Photo-Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell- and Tissue-Based Proteome Profiling

Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein

Technology Spotlight: Trifuctional Probe Building Blocks

Informations sur la sécurité

• Pictogrammes: GHS02
• Mention d'avertissement: Danger
• Mentions de danger: H242
• Conseils de prudence: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Classification des risques: Self-react. C
• Code de la classe de stockage: 5.2 - Organic peroxides and self-reacting hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable