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731765

Sigma-Aldrich

Poly(ethylene glycol) methyl ether maleimide

average Mn 2,000, maleimide, methoxy, chemical modification reagent thiol reactive

Synonyme(s) :

Polyethylene glycol, Methoxy PEG maleimide, PEG methyl ether maleimide

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About This Item

Formule linéaire :
CH3O(CH2CH2O)nCH2CH2OC(O)CH2CH2CH2N[C(O)]2CHCH
Code UNSPSC :
12162002
Nomenclature NACRES :
NA.23

product name

Poly(ethylene glycol) methyl ether maleimide, average Mn 2,000

Forme

solid

Poids mol.

average Mn 2,000

Pertinence de la réaction

reagent type: chemical modification reagent
reactivity: thiol reactive

Pf

48-52 °C

Mw/Mn

<1.1

Extrémité Ω

maleimide

Extrémité α

methoxy

Architecture des polymères

shape: linear
functionality: monofunctional

Application

Poly(ethylene glycol) methyl ether maleimide is a maleimide-functionalized poly(ethylene glycol). Due to the maleimide-functionalization, this material can be used to rapidly conjugate thiol-containing biomolecules, APIs, or targeting ligands.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Karina L Heredia et al.
Macromolecules, 42(7), 2360-2367 (2009-01-01)
In this report we describe a straightforward approach to synthesize polymers with end-groups that bind site-specifically to two different proteins. Telechelic biotin, maleimide poly(N-isopropylacrylamide) (pNIPAAm) was synthesized for the formation of streptavidin (SAv)-bovine serum albumin (BSA) polymer conjugates. Reversible addition-fragmentation

Articles

Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Versatile Cell Culture Scaffolds: Bio-orthogonal Click

Designing biomaterial scaffolds mimicking complex living tissue structures is crucial for tissue engineering and regenerative medicine advancements.

Versatile Cell Culture Scaffolds: Bio-orthogonal Click

Designing biomaterial scaffolds mimicking complex living tissue structures is crucial for tissue engineering and regenerative medicine advancements.

Versatile Cell Culture Scaffolds: Bio-orthogonal Click

Designing biomaterial scaffolds mimicking complex living tissue structures is crucial for tissue engineering and regenerative medicine advancements.

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