Accéder au contenu
MilliporeSigma

Cognitive changes after saline or plasmalyte infusion in healthy volunteers: a multiple blinded, randomized, cross-over trial.

Anesthesiology (2013-04-20)
David A Story, Lucy Lees, Laurence Weinberg, Soon-Yee Teoh, Katherine J Lee, Sarah Velissaris, Rinaldo Bellomo, Sarah J Wilson
RÉSUMÉ

In an incidental finding, during a study of plasma chemistry after crystalloid infusion, participants reported subjective cognitive changes, particularly slower thinking, after saline but not Hartmann's (Ringer's lactate) solution. The authors tested the hypothesis that saline infusion would produce greater adverse cognitive changes than Plasmalyte infusion. The authors conducted a randomized, cross-over, multiple blinded study of healthy adult volunteers. On separate days, participants received 30 ml/kg over 1 h of either 0.9% saline or Plasmalyte with the order randomly allocated. Plasma chemistry was tested on venous samples. As part of a battery of cognitive tests our primary endpoint was the reaction time index after infusion. The authors studied 25 participants. Plasma chloride was greater after saline than after Plasmalyte: mean difference 5.4 mM (95% CI, 4.1-6.6 mM; P < 0.001). Saline was also associated with greater metabolic acidosis: base-excess 2.5 mM more negative (95% CI, 1.9-3.0 mM more negative; P < 0.001). There was no evidence of a difference in the reaction time index between the two interventions: mean reaction time index 394 ms (SD, 72) after saline versus 385 ms (SD, 55) after Plasmalyte. Difference: saline 9 ms slower (95% CI, 30 ms slower to 12 ms faster; P = 0.39). There were minimal differences in the other cognitive and mood tests. Despite expected differences in plasma chemistry, the authors found that measures of cognition did not differ after infusions of Plasmalyte or saline.

MATÉRIAUX
Référence du produit
Marque
Description du produit

Sigma-Aldrich
Chlorure de potassium, ACS reagent, 99.0-100.5%
Sigma-Aldrich
Acétate de sodium trihydrate, ACS reagent, ≥99%
Sigma-Aldrich
Chlorure de magnésium solution, for molecular biology, 1.00 M±0.01 M
Sigma-Aldrich
Chlorure de magnésium, anhydrous, ≥98%
Sigma-Aldrich
Chlorure de potassium, for molecular biology, ≥99.0%
Sigma-Aldrich
Chlorure de potassium, puriss., meets analytical specification of Ph. Eur., BP, USP, FCC, E508, 99-100.5% (AT), ≤0.0001% Al
Sigma-Aldrich
Chlorure de potassium, powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99.0%
Sigma-Aldrich
Acétate de sodium trihydrate, ReagentPlus®, ≥99.0%
Sigma-Aldrich
Chlorure de potassium, ReagentPlus®, ≥99.0%
Sigma-Aldrich
Chlorure de potassium solution, BioUltra, for molecular biology, ~1 M in H2O
Sigma-Aldrich
Chlorure de magnésium, powder, <200 μm
Sigma-Aldrich
Chlorure de potassium, BioUltra, for molecular biology, ≥99.5% (AT)
Sigma-Aldrich
Chlorure de potassium, puriss. p.a., ≥99.5% (AT)
Sigma-Aldrich
Acétate de sodium trihydrate, puriss., meets analytical specification of Ph. Eur., BP, USP, FCC, E262, 99.0-101.0% (calc. to the dried substance), ≤0.00002% Al
Sigma-Aldrich
Chlorure de magnésium solution, BioUltra, for molecular biology, 2 M in H2O
Sigma-Aldrich
Chlorure de magnésium, BioReagent, suitable for insect cell culture, ≥97.0%
Supelco
Potassium chloride solution, for Ag/AgCl electrodes, ~3 M KCl, saturated with silver chloride
Sigma-Aldrich
Chlorure de potassium, 99.999% trace metals basis
Sigma-Aldrich
Chlorure de magnésium solution, BioUltra, for molecular biology, ~1 M in H2O
Sigma-Aldrich
Chlorure de potassium, BioXtra, ≥99.0%
Sigma-Aldrich
Chlorure de magnésium solution, PCR Reagent, 25 mM MgCI2 solution for PCR
Sigma-Aldrich
Chlorure de magnésium, AnhydroBeads, −10 mesh, 99.9% trace metals basis
Sigma-Aldrich
Acétate de sodium trihydrate, BioUltra, ≥99.5% (NT)
Supelco
Chlorure de potassium solution, BioUltra, ~3 M in H2O
Sigma-Aldrich
Chlorure de potassium, ≥99.99% trace metals basis
Sigma-Aldrich
Acétate de sodium trihydrate, BioXtra, ≥99.0%
Sigma-Aldrich
Chlorure de magnésium, AnhydroBeads, −10 mesh, 99.99% trace metals basis
Sigma-Aldrich
Chlorure de potassium solution, 0.075 M, sterile-filtered, BioXtra, suitable for cell culture
Sigma-Aldrich
Chlorure de magnésium solution, 0.1 M
Supelco
Chlorure de potassium solution, 1 M KCl