GF315
VEGF165 Protein, Human Recombinant Animal Free
The Vascular endothelial growth factor (VEGF or VEGFA) is a potent mediator of both angiogenesis & vasculogenesis in the fetus & adult. Manufactured using all non-animal reagents.
Synonyme(s) :
Vascular Endothelial Growth Factor 165, VEGF-165, VEGF, Vascular Endothelial Growth Factor, VEGF-A
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About This Item
Code UNSPSC :
12352202
eCl@ss :
32160405
Nomenclature NACRES :
NA.77
Produits recommandés
Niveau de qualité
Pureté
>98% (SDS-PAGE and HPLC)
Impuretés
<0.1 μg/mg protein endotoxin (<1EU/μg)
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Catégories apparentées
Description générale
Product Source: E. coli
Vascular endothelial growth factor (VEGF or VEGFA) is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. Humans express alternately spliced isoforms of 121, 145, 165, 183, 189, and 206 amino acids (aa) in length. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant human VEGF is a 38.2 kDa disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.
Spécificité
Cross Reactivty
Mouse, Rat, Pig, Hamster, Trout, Green Algae, Sheep, Cow, Rabbit, Guinea Pig
Mouse, Rat, Pig, Hamster, Trout, Green Algae, Sheep, Cow, Rabbit, Guinea Pig
Application
Research Category
Stem Cell Research
Stem Cell Research
Research Sub Category
Growth Factors & Receptors
Growth Factors & Receptors
Qualité
Bioactivity assay: Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 1.0-8.0 ng/ml.
Forme physique
Product is filtered through a 0.2 micron filter before lyophilization.
Recombinant animal free human VEGF165 is manufactured using all non-animal reagents
Stockage et stabilité
Store at -20°C for up to 6 months from date of receipt.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
John P Morgan et al.
Nature protocols, 8(9), 1820-1836 (2013-08-31)
This protocol describes how to form a 3D cell culture with explicit, endothelialized microvessels. The approach leads to fully enclosed, perfusable vessels in a bioremodelable hydrogel (type I collagen). The protocol uses microfabrication to enable user-defined geometries of the vascular
Wutigri Nimlamool et al.
Molecular biology of the cell, 26(15), 2755-2768 (2015-06-13)
Gap junctions (GJs) exhibit a complex modus of assembly and degradation to maintain balanced intercellular communication (GJIC). Several growth factors, including vascular endothelial growth factor (VEGF), have been reported to disrupt cell-cell junctions and abolish GJIC. VEGF directly stimulates VEGF-receptor
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