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T8806

Sigma-Aldrich

Thymopentin

≥97% (HPLC)

Synonyme(s) :

TP5, Arg-Lys-Asp-Val-Tyr

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About This Item

Formule empirique (notation de Hill):
C30H49N9O9
Numéro CAS:
69558-55-0
Poids moléculaire :
679.76
Numéro MDL:
MFCD00214200
Code UNSPSC :
12352209
ID de substance PubChem :
329826886
Nomenclature NACRES :
NA.26

Nom du produit

Thymopentin, ≥97% (HPLC)

Niveau de qualité

200

Essai

≥97% (HPLC)

Forme

powder

Couleur

white

Application(s)

cell analysis

Température de stockage

−20°C

Chaîne SMILES 

CC(C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O

InChI

1S/C30H49N9O9/c1-16(2)24(28(46)38-22(29(47)48)14-17-8-10-18(40)11-9-17)39-27(45)21(15-23(41)42)37-26(44)20(7-3-4-12-31)36-25(43)19(32)6-5-13-35-30(33)34/h8-11,16,19-22,24,40H,3-7,12-15,31-32H2,1-2H3,(H,36,43)(H,37,44)(H,38,46)(H,39,45)(H,41,42)(H,47,48)(H4,33,34,35)/t19-,20-,21-,22-,24-/m0/s1

Clé InChI

PSWFFKRAVBDQEG-YGQNSOCVSA-N

Amino Acid Sequence

Arg-Lys-Asp-Val-Tyr

Description générale

Thymopentin (TP5) is a pentapeptide produced by the epithelial cells of the thymic cortex and medulla. It consists of thymosin α1 (Tα1).[1]

Actions biochimiques/physiologiques

Thymopentin (TP5) is an immunomodulator, resembling the active site of the thymopoietin. TP5 stimulates cellular immune responses such as T-cell formation,[1] natural killer (NK) cell and macrophage activation,[2] generation of cytokines, and activation of B-cell for antibody production. It also mimics the polypeptide environment of the thymus.[1] TP5 is used to treat conditions like immune deficiency, autoimmune diseases, infections, and cancers. It has a short half-life and is rapidly metabolized in the gastrointestinal tract.[3]

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
SLCJ1921
SLBQ5860V
SLBN5912V
SLBC4992V
120M1626V

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

V K Singh et al.
Immunologic research, 17(3), 345-368 (1998-06-25)
Splenopentin (SP-5, Arg-Lys-Glu-Val-Tyr) and thymopentin (TP-5, Arg-Lys-Asp-Val-Tyr) are synthetic immunomodulating peptides corresponding to the region 32-34 of a splenic product called splenin (SP) and the thymic hormone thymopoietin (TP), respectively. TP was originally isolated as a 5-kDa (49-amino acids) protein
Yan Zhang et al.
International journal of pharmaceutics, 386(1-2), 15-22 (2009-11-10)
Copolymers were synthesized by ring opening polymerization of l- or d-lactide in the presence of dihydroxyl PEG with molar mass of 6000, 12,000 and 20,000, using zinc lactate as catalyst. Bioresorbable hydrogels were obtained by mixing PLLA-PEG-PLLA and PDLA-PEG-PDLA aqueous
Jing Gao et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 36(4-5), 572-579 (2009-01-13)
Thymopentin (TP5), a synthetic pentapeptide, has been used in clinic as a modulator for immunodeficiences through intramuscular administration. The purpose of this study was to design and evaluate dry powder inhalations (DPIs) for pulmonary delivery of TP5. Dry powder inhalations
G Goldstein et al.
Survey of immunologic research, 4 Suppl 1, 1-10 (1985-01-01)
Thymopoietin is a polypeptide hormone of the thymus consisting of 49 amino acids. The pentapeptide thymopentin (TP-5) Arg-Lys-Asp-Val-Tyr, corresponding to amino acids 32-36 of thymopoietin, appears to represent the active site of thymopoietin in that it has all the biological
E Sundal
The British journal of clinical practice, 47(4), 198-204 (1993-07-01)
Present immunological methods do not regularly detect abnormalities in patients with chronic bronchitis, and no single parameter appears to be closely associated with the clinical findings. Of the many tests performed in the cited studies, the Merieux multitest procedure seems
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