SML0081

Zacopride hydrochloride hydrate

≥98% (HPLC)

• Synonyme(s) : 4-Amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxybenzamide hydrochloride hydrate
• Formule empirique (notation de Hill) : C₁₅H₂₀ClN₃O₂ · HCl · xH₂O
• Numéro CAS: 101303-98-4
• Poids moléculaire : 346.25 (anhydrous basis)
• Numéro MDL: MFCD20488057
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825143
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to tan
• Solubilité: H₂O: ≥10 mg/mL
• Auteur: Wyeth
• Température de stockage: 2-8°C
• Chaîne SMILES: O.Cl.COc1cc(N)c(Cl)cc1C(=O)NC2CN3CC[C@H]2CC3
• InChI: 1S/C15H20ClN3O2.ClH.H2O/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19;;/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20);1H;1H2
• Clé InChI: NPXXKMBXEODDAF-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

Serotonin 5-HT3 and 5-HT4 receptor antagonist

Zacopride is a sub-nanomolar antagonist of the serotonin 5-HT3 receptor that also displays agonist-like activity against 5-HT4 receptors. It is a potent anxiolytic in animal models, and also has strong antiemetic effects, and also increases aldosterone levels via activation of 5-HT4 receptor in the adrenal glands.

Caractéristiques et avantages

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable