PZ0171

CP-100356 monohydrochloride

>98% (HPLC), powder, MDR1 (P-Gp) inhibitor

• Synonyme(s) : 4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxy-2-quinazolinamine monohydrochloride
• Formule empirique (notation de Hill): C₃₁H₃₆N₄O₆ · HCl
• Numéro CAS: 142715-48-8
• Poids moléculaire : 597.10
• Numéro MDL: MFCD00911858
• Code UNSPSC : 12161501
• ID de substance PubChem : 329823745
• Nomenclature NACRES : NA.77

Propriétés

• product name: CP-100356 monohydrochloride, >98% (HPLC)
• Pureté: >98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to off-white
• Solubilité: DMSO: >5 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: Cl.COc1ccc(CCNc2nc(N3CCc4cc(OC)c(OC)cc4C3)c5cc(OC)c(OC)cc5n2)cc1OC
• InChI: 1S/C31H36N4O6.ClH/c1-36-24-8-7-19(13-25(24)37-2)9-11-32-31-33-23-17-29(41-6)28(40-5)16-22(23)30(34-31)35-12-10-20-14-26(38-3)27(39-4)15-21(20)18-35;/h7-8,13-17H,9-12,18H2,1-6H3,(H,32,33,34);1H
• Clé InChI: WWCHXVYTCMPAMV-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. The compound has low uM to nM potency for inhibiting several MDR-1 substrates (calcein-AM, digoxin) in transfected MDCKII cells. CP-100356 also inhibits prazosin transport in human breast cancer resistance protein (BCRP)-transfected MDCKII cells, suggesting that it acts as a dual inhibitor. CP-100356 does not inhibit multidrug resistance-associated protein 2 (MPR2 IC₅₀ >15 mM).

Caractéristiques et avantages

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable