P9255

Pyridoxal 5′-phosphate hydrate

≥98%

• Synonyme(s) : Pyridoxal phosphate, 3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde, Codecarboxylase, PLP, Pyridoxal 5-phosphate
• Formule empirique (notation de Hill) : C₈H₁₀NO₆P · xH₂O
• Numéro CAS: 853645-22-4
• Poids moléculaire : 247.14 (anhydrous basis)
• Beilstein: 234749
• Numéro CE : 200-208-3
• Numéro MDL: MFCD00006333
• Code UNSPSC : 12352205
• ID de substance PubChem : 24899020
• Nomenclature NACRES : NA.79

Propriétés

• Source biologique: synthetic (organic)
• Essai: ≥98%
• Forme: powder
• Technique(s): HPLC: suitable
• Couleur: beige; off-white to yellow
• Pf: 140-143 °C
• Température de stockage: −20°C
• Chaîne SMILES: CC1=NC=C(COP(O)(O)=O)C(C([H])=O)=C1O
• InChI: 1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
• Clé InChI: NGVDGCNFYWLIFO-UHFFFAOYSA-N

Description

Description générale

Pyridoxal 5′-phosphate (PLP) is synthesized in a multiple-step process. The two pathways inlcude pyridoxal phosphate biosynthetic protein (PdxA)- pyridoxine-5′-phosphate synthase (PdxJ) pathway and the pyridoxal 5′-phosphate synthase subunit PDX1/PDX2 pathway.[1] It is the active form of pyridoxine.[2]

Application

Pyridoxal 5′-phosphate hydrate has also been used:

• as a reference standard to quantify vitamin B₆ in feed and digesta samples using high performance liquid chromatography (HPLC)[3]
• in D-amino acid transaminase reaction(10)
• as a cofactor for L-glutamic acid decarboxylase[4]

Actions biochimiques/physiologiques

Pyridoxal 5′-phosphate (PLP) aids in carbohydrate and fat metabolism by serving as a cofactor. It is majorly responsible for catalyzing the enzymatic reactions involved in sphingolipid synthesis and neurotransmitter (dopamine and serotonin) synthesis.[2] PLP is used in the studies of PLP-dependent enzyme active sites. PLP is also a cofactor for a wide range of enzymes including mitochondrial 5-Aminolevulinic acid synthase (ALAS)[5] cysteine desulfurase,[6] cystathionine γ-synthase (CGS),[7] ornithine 4,5-aminomutase (OAM),[8] and D-serine dehydratase.[9]

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)