P5585

Acide palmitique

BioXtra, ≥99%

• Synonyme(s) : 1-Pentadecanecarboxylic acid, C16:0, Cetylic acid, Hexadecanoic acid, NSC 5030, PamOH
• Formule linéaire : CH₃(CH₂)₁₄COOH
• Numéro CAS: 57-10-3
• Poids moléculaire : 256.42
• Beilstein: 607489
• Numéro CE : 200-312-9
• Numéro MDL: MFCD00002747
• Code UNSPSC : 12352106
• ID de substance PubChem : 24898674
• Nomenclature NACRES : NA.25

Propriétés

• Source biologique: plant (vegetable)
• Qualité: BioPerformance Certified
• Pression de vapeur: 10 mmHg ( 210 °C)
• Gamme de produits: BioXtra
• Essai: ≥99%
• Forme: powder
• Technique(s): cell culture | mammalian: suitable
• Impuretés: ≤0.0005% Phosphorus (P); ≤0.1% Insoluble matter
• Résidus de calcination: ≤0.1%
• pb: 271.5 °C/100 mmHg (lit.)
• Pf: 61-62.5 °C (lit.)
• Solubilité: chloroform: 0.5 M, clear, colorless
• Densité: 0.852 g/mL at 25 °C (lit.)
• Traces d'anions: chloride (Cl^-): ≤0.05%; sulfate (SO₄^2-): ≤0.05%
• Traces de cations: Al: ≤0.005%; Ca: ≤0.0005%; Cu: ≤0.0005%; Fe: ≤0.0005%; K: ≤0.005%; Mg: ≤0.0005%; NH₄⁺: ≤0.05%; Na: ≤0.05%; Pb: ≤0.001%; Zn: ≤0.0005%
• Groupe fonctionnel: carboxylic acid
• Type de lipide: saturated FAs
• Conditions d'expédition: ambient
• Température de stockage: room temp
• Chaîne SMILES: CCCCCCCCCCCCCCCC(O)=O
• InChI: 1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)
• Clé InChI: IPCSVZSSVZVIGE-UHFFFAOYSA-N
• Informations sur le gène: human ... FABP2(2169) , FABP3(2170) , FABP4(2167) , FABP5(2171)

Description

Application

Palmitic acid has been used:

• as a medium supplement in chorionic villous tissue culture form placenta[1]
• as a component of hormone pellet for implantation in mice ovary[2]
• for inducing expression of immunity-related GTPase M (IRGM) in human monocytic cell line, THP-1[3]

Actions biochimiques/physiologiques

Palmitic acid (PA) is a component of membrane phospholipids (PL) and adipose triacylglycerols (TAG).[4] Elevated levels of palmitic acid contributes to the pathophysiology of atherosclerosis, type 2 diabetes mellitus, neurodegenerative diseases, obesity and cancer.[4][5] PA promotes apoptosis in the endothelial cell by modulating the p38 mitogen-activated protein kinase (MAPK) pathway and favors expression of TNF-α and reactive oxygen species accumulation.[6] PA promotes interleukin 8 (IL-8) synthesis in hepatocytes contributing to hepatic inflammation.[7] PA by interacting with toll-like receptor 4 (TLR4) induces inflammatory injury in cardiomyoctes.[8]

Palmitic acid is a straight-chain 16-carbon fatty acid. Diets rich in palmitic acid, along with lauric and myristic acids, are associated with increased serum levels of low-density lipoprotein cholesterol. Palmitic acid is the first fatty acid produced by lipogenesis. It is a negative regulator of acetyl-CoA carboxylase (ACC) and is implicated in fatty acid-induced insulin resistance.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): nwg
• Point d'éclair (°F): 235.4 °F
• Point d'éclair (°C): 113 °C
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves