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L4170

Sigma-Aldrich

LDN-57444

≥98% (HPLC)

Synonyme(s) :

3-(O-acetyloxime), 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-Indole-2,3-dione, C30, LDN 57444

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About This Item

Formule empirique (notation de Hill):
C17H11Cl3N2O3
Numéro CAS:
668467-91-2
Poids moléculaire :
397.64
Numéro MDL:
MFCD09037562
Code UNSPSC :
12352200
ID de substance PubChem :
329817408
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

solid

Conditions de stockage

desiccated
protect from light

Solubilité

DMSO: 16 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

CC(=O)O\N=C1/C(=O)N(Cc2cc(Cl)ccc2Cl)c3ccc(Cl)cc13

InChI

1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H,8H2,1H3/b21-16-

Clé InChI

OPQRFPHLZZPCCH-PGMHBOJBSA-N

Actions biochimiques/physiologiques

LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Amanda J Steiman et al.
The Journal of rheumatology, 41(9), 1808-1816 (2014-08-03)
Systemic lupus erythematosus (SLE) is typically a relapsing/remitting disease. However, some patients experience prolonged remission. These patients may provide further insights into SLE pathophysiology. In this study we characterize their clinical course. Prolonged remission was defined as Systemic Lupus Erythematosus
Lorena Ruiz de Larrinaga et al.
Nutrients, 11(7) (2019-07-07)
Vegetables, once harvested and stored on supermarket shelves, continue to perform biochemical adjustments due to their modular nature and their ability to retain physiological autonomy. They can live after being harvested. In particular, the content of some essential nutraceuticals, such
Anna Wing et al.
Cancer immunology research, 6(5), 605-616 (2018-03-29)
T cells expressing chimeric antigen receptors (CART) have shown significant promise in clinical trials to treat hematologic malignancies, but their efficacy in solid tumors has been limited. Oncolytic viruses have the potential to act in synergy with immunotherapies due to
Giulia Chitarrini et al.
Protoplasma, 254(6), 2095-2106 (2017-03-23)
Metabolic changes can occur in plants in response to abiotic stress. Extensive use of leaf discs (mechanical wounding) in studies regarding the effect on the biochemical response of the grapevine to different types of biotic stress makes it necessary to
K Beernaert et al.
European journal of cancer care, 25(4), 534-543 (2016-06-09)
Despite the growing consensus on the benefits of initiating palliative care early in the disease trajectory, it remains unclear at what point palliative care needs emerge. This study investigates quality of life and unmet palliative care needs at three phases
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