H3281

Hematin porcine

• Synonyme(s) : Ferrihemate, Hematin porcine
• Formule linéaire : C₃₄H₃₃N₄O₅Fe
• Numéro CAS: 15489-90-4
• Poids moléculaire : 633.49
• Numéro CE : 239-518-9
• Numéro MDL: MFCD00011615
• Code UNSPSC : 12352202
• ID de substance PubChem : 24895570
• Nomenclature NACRES : NA.61

Propriétés

• Source biologique: Porcine
• Forme: powder
• Température de stockage: 2-8°C
• Chaîne SMILES: Cc1c(CCC(O)=O)c2cc3c(CCC(O)=O)c(C)c4cc5nc(cc6c(C=C)c(C)c(cc1n2)n6[Fe](O)n34)c(C)c5C=C
• InChI: 1S/C34H34N4O4.Fe.H2O/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);;1H2/q;+3;/p-3/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;
• Clé InChI: BMUDPLZKKRQECS-HXFTUNQESA-K
• Informations sur le gène: pig ... MCOLOR(100530327)

Description

Application

Hematin porcine has been used as a:

• polymerase chain reaction (PCR) inhibitor to evaluate its effect on the PowerQuant System used for detecting degraded DNA in samples
• supplement in Haemophilus test medium to culture Haemophilus influenzae isolates for resistance studies
• standard to determine the heme coefficient as a part of heme iron analysis using raw beef lung

Hematin was used in a study to test in vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. It was also used in a study to test in-vitro bacterial identification using fluorescence spectroscopy with an optical fiber system.

Actions biochimiques/physiologiques

Hematin is a hydroxide of heme. It may be used to treat acute porphyric attacks. Hematin suppresses the hepatic aminolevulinic acid (ALA) function and replenishes cytochrome action by restoring the endogenous heme deficit. Early administration of hematin can prevent irreversible neuronal damage induced due to metabolic disorders.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)