C111000

DMT-dC(bz) Phosphoramidite

• Synonyme(s) : N4-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxycytidine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]
• Formule empirique (notation de Hill): C₄₆H₅₂N₅O₈P
• Numéro CAS: 102212-98-6
• Poids moléculaire : 833.91
• Numéro MDL: MFCD00036315
• Code UNSPSC : 41116107
• ID de substance PubChem : 329774845
• Nomenclature NACRES : NA.51

Propriétés

• Source biologique: non-animal source (no BSE/TSE risk)
• Niveau de qualité: 200
• Type: for DNA synthesis
• Gamme de produits: Proligo Reagents
• Pureté: ≥99% (³¹P-NMR); ≥99.0% (reversed phase HPLC)
• Forme: powder or granules
• Technique(s): oligo synthesis: suitable
• Impuretés: ≤0.3 wt. % water content (Karl Fischer)
• Couleur: white to off-white
• λ: conforms (UV/VIS Identity)
• Profil des nucléosides: base: deoxycytidine; base protecting group: benzoyl; 2' protecting group: none; 5' protecting group: DMT; deprotection: standard
• Température de stockage: 2-8°C
• Chaîne SMILES: COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)N3C=CC(NC(=O)c4ccccc4)=NC3=O)(c5ccccc5)c6ccc(OC)cc6
• InChI: 1S/C46H52N5O8P/c1-32(2)51(33(3)4)60(57-29-13-27-47)59-40-30-43(50-28-26-42(49-45(50)53)48-44(52)34-14-9-7-10-15-34)58-41(40)31-56-46(35-16-11-8-12-17-35,36-18-22-38(54-5)23-19-36)37-20-24-39(55-6)25-21-37/h7-12,14-26,28,32-33,40-41,43H,13,29-31H2,1-6H3,(H,48,49,52,53)/t40-,41+,43+,60?/m0/s1
• Clé InChI: PGTNFMKLGRFZDX-SALLYJDFSA-N

Description

Description générale

DMT-dC(bz) Phosphoramidite belongs to the group of DNA Phosphoramidites.Its key features include:

• Exocyclic amine functions are protected by a benzoyl group (dA(bz) anddC(bz)) or isobutyryl group (dG(ib))
• Recommended cleavage and deprotection conditions are 8 hours at 55 °Cor 24 hours at room temperature using concentrated ammonia solution, for standard base-protected oligonucleotides
• The high coupling efficiency of Proligo′s DNA phosphoramidites leads to high-yield and high-quality oligonucleotides