SCC733

3dGRO^® Colorectal Organoids (POP.141.G2)

• Synonyme(s) : organoid, PDO, cancer organoid, tumor organoid, 3d cell culture, colorectal cancer
• Code UNSPSC : 41106514
• Nomenclature NACRES : NA.21

Propriétés

• Source biologique: human
• Niveau de qualité: 100
• Conditionnement: vial of ≥1500 organoids/vial vials
• Fabricant/nom de marque: Millipore
• Technique(s): cell culture | mammalian: suitable; cell culture | stem cell: suitable
• Conditions d'expédition: liquid nitrogen
• Température de stockage: −196°C

Description

Description générale

Colorectal cancer accounts for roughly 10% of all cancer cases worldwide with more than half of all patients with CRC developing metastatic disease leading to death. Recently, tissue derived organoids have emerged as a more predictive 3 dimensional cell culture model of disease. 3D organoid cultures conserve the original genetic and phenotypic characteristics of the primary tissue allowing for their application in many research fields included drug development, personalized medicine and potential therapeutics. In vitro cultured tumor organoids have also been shown to predict patient response to chemotherapeutics. PDOs derived from colorectal cancer (CRC organoids) have been used for cell modeling and to investigate the function of cancer related driver gene mutations including APC, TP53, KRAS, BRAF, PIK3CA etc.

We are now offering a comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients. The intestinal organoid biobank contains over 50 highly characterized intestinal organoids from both normal and diseased patients derived from multiple regions of the digestive systems including small intestine (duodenum, ileum), stomach, rectum and colon.

Cell Line Characteristics

• Sex: Male
• Age: 57 Years
• Organ: Colon (Xenograph from Primary Tumor, Liver Metastasis)
• Disease: Adenocarcinoma (KRAS Mutation: G12D)

Application

• Viability: >=1500 viable organoids/vial
• Organoid Growth: Pass
• Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Mycoplasma Contamination: Negative
• STR Profile: Pass

Caractéristiques et avantages

Cryopreserved patient derived colorectal cancer organoids (PDOs)

Stockage et stabilité

Store in liquid nitrogen. The organoids can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Informations légales

3dGRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable