8.51010

PyBroP

Novabiochem^®

• Synonyme(s) : PyBroP, Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate
• Formule empirique (notation de Hill): C₁₂H₂₄BrN₃P · F₆P
• Numéro CAS: 132705-51-2
• Poids moléculaire : 466.18
• Numéro MDL: MFCD00077412
• Code UNSPSC : 12352107
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 200
• Gamme de produits: Novabiochem^®
• Pureté: ≥98.0% (HPLC)
• Forme: powder
• Capacité de réaction: reaction type: Coupling Reactions
• Fabricant/nom de marque: Novabiochem^®
• Pf: >100 °C
• Application(s): peptide synthesis
• Température de stockage: 2-8°C
• InChI: 1S/C12H24BrN3P.F6P/c13-17(14-7-1-2-8-14,15-9-3-4-10-15)16-11-5-6-12-16;1-7(2,3,4,5)6/h1-12H2;/q+1;-1
• Clé InChI: CYKRMWNZYOIJCH-UHFFFAOYSA-N

Description

Description générale

A superior reagent for rapid and effective coupling of N-methyl amino acids with low enantiomerization and for other critical applications ^{[1,2,3,4,5,6,7,8]}. The coupling of N-methyl amino acids is difficult, and usually only gives low to moderate yields of products which are often contaminated with unwanted diastereomers. Many coupling reagents are ineffective or not practical to use: BOP and HOBt are often useless; BOP-Cl, pivaloyl chloride and Dpp-Cl require long reaction times and preactivation at 0°C.For coupling γ-aminoisobutyric acid (Aib), PyBrOP^® is most effective when used with dimethylaminopyridine (DMAP) ^[3].

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents


Literature references

^[1] J. Coste, et al. in ′Peptides, Chemistry, Structure & Biology, Proc. 11th American Peptide Symposium′, J. E. Rivier & G. R. Marshall (Eds), ESCOM, Leiden, 1990, pp. 900.
^[2] J. Coste, et al. (1990) Tetrahedron Lett., 31, 669.
^[3] J. Coste, et al. in ′Peptides 1990, Proc. 21st European Peptide Symposium′, E. Giralt & D. Andreu (Eds), ESCOM, Leiden, 1990, pp. 76.
^[4] J. Coste, et al. (1991) Tetrahedron Lett., 32, 1967.
[5] P. W. Baures, et al. (1997) J. Peptide Res., 50, 1.
^[6] T. Doi, et al. (1999) Synlett, 11, 1751.
^[7] A. M. Boldi, et al. (2001) J. Comb. Chem., 3, 367.
^[8] S. Gazal, et al. (2001) J. Peptide Res., 58, 527.

Liaison

Replaces: 01-62-0017

Remarque sur l'analyse

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 98.0 % (a/a)

Informations légales

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

PyBroP is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS05
• Mention d'avertissement: Danger
• Mentions de danger: H314
• Conseils de prudence: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Classification des risques: Eye Dam. 1 - Skin Corr. 1B
• Code de la classe de stockage: 8A - Combustible, corrosive hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable