407325

Interferon-α-IFNα-R Interaction Inhibitor

The Interferon-α-IFNα-R Interaction Inhibitor controls the biological activity of Interferon-α-IFNα-R.

• Synonyme(s) : Interferon-α-IFNα-R Interaction Inhibitor, IFN-α Inhibitor, N-Methyl-1-(2-(naphthalen-1-ylthio)phenyl)methanamine, HCl, N-Methyl-N-(2-(1-naphthylthio)benzyl)amine, HCl, N-Methyl-1-(2-(naphthalen-1-ylthio)phenyl)methanamine, HCl, N-Methyl-N-(2-(1-naphthylthio)benzyl)amine, HCl, IFN-α Inhibitor
• Formule empirique (notation de Hill): C₁₈H₁₇NS · xHCl
• Poids moléculaire : 279.40 (free base basis)
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.32

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic); protect from light
• Couleur: white
• Solubilité: DMSO: 50 mg/mL, clear, colorless
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: CNCC1=CC=CC=C1SC2=CC=CC3=C2C=CC=C3.[xHCl]

Description

Description générale

A nonpeptidic thiophenylmethanamine compound that binds interferon-α (K_d = 4 µM for human IFN-α) and prevents IFN-α and IFNAR interaction-dependent IFN-α production in murine BM-pDCs (bone marrow-derived plasmacytoid dendritic cells) cultures upon MVA (vaccinia virus Ankara) infection (IC₅₀<4.5 µM), TLR9 ligand CpG2216 stimulation, VSV-M2 (vesicular stomatitis virus variant 2) infection, or MDA5/TLR3 ligand poly(I:C) stimulation (by >95% inhibition at 9 µM), while exhibiting no inhibitory effect against IL-12 production in the same cultures when applied at non-toxic concentrations (≤4.5 µM).

A nonpeptidic thiophenylmethanamine compound that binds interferon-α (K_d = 4 µM for human IFN-α) and prevents IFN-α and IFNAR interaction-dependent IFN-α production in murine BM-pDCs (bone marrow-derived plasmacytoid dendritic cells) cultures upon MVA infection (IC₅₀<4.5 µM), while exhibiting no inhibitory effect against IL-12 production in the same cultures when applied at non-toxic concentrations (≤4.5 µM).

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Geppert, T., et al. 2011. Angew. Chem. Int. Ed.51, 258.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable