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189826

Sigma-Aldrich

5-Aza-2′-Deoxycytidine

≥98% (HPLC), liquid, DNA methyltransferase inhibitor, Calbiochem

Synonyme(s) :

InSolution 5-Aza-2′-Deoxycytidine, Decitabine

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About This Item

Formule empirique (notation de Hill):
C8H12N4O4
Numéro CAS:
2353-33-5
Poids moléculaire :
228.21
Numéro MDL:
MFCD00043011
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

product name

5-Aza-2′-Deoxycytidine, InSolution, ≥98%, DNA methyltransferase inhibitor

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

liquid

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze
desiccated (hygroscopic)
protect from light

Conditions d'expédition

ambient

Température de stockage

−20°C

InChI

1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)

Clé InChI

XAUDJQYHKZQPEU-UHFFFAOYSA-N

Description générale

A cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. The solid form of this compound (Cat. No. 189825) is also available.

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Regulatory Review (Z)

Forme physique

A 100 mM (10 mg/438 µl) solution of 5-Aza-2ʹ-Deoxycytidine (Cat. No. 189825) in DMSO.

Autres remarques

Eggert, A., et al. 2001. Cancer Res.61, 1314.
Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun.288, 921.
Zhu, W.G., et al. 2001. Cancer Res.61, 1327.
Hopkins-Donaldson, S., et al. 2000. Cancer Res.60, 4315.
Haaf, T. 1995. Pharmacol. Ther.65, 19.
Jones, P.A., and Taylor, S.M. 1980. Cell20, 85.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Danger

Mentions de danger

H341,H360

Classification des risques

Muta. 2 - Repr. 1B

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

188.6 °F - closed cup - (Dimethylsulfoxide)

Point d'éclair (°C)

87 °C - closed cup - (Dimethylsulfoxide)

Certificats d'analyse (COA)

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