This product may be stored at -20°C in aliquots at least until the recommended retest date published in the Certificate of Analysis. Avoid repeated freeze/thaw cycles.
T1952
Trichostatin A, Ready Made Solution
5 mM in DMSO, from Streptomyces sp.
Synonyme(s) :
TSA, Trichostatin A, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
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About This Item
Formule empirique (notation de Hill) :
C17H22N2O3
Numéro CAS:
Poids moléculaire :
302.37
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32
104,00 $
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Produits recommandés
Source biologique
Streptomyces sp.
Niveau de qualité
Essai
≥98% (HPLC)
Forme
DMSO solution
Concentration
5 mM in DMSO
Technique(s)
cell culture | mammalian: suitable
Spectre d'activité de l'antibiotique
fungi
neoplastics
Mode d’action
enzyme | inhibits
Conditions d'expédition
dry ice
Température de stockage
−20°C
Chaîne SMILES
N(O)C(=O)\C=C\C(=C\C(C)C(=O)c1ccc(cc1)N(C)C)\C
InChI
1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+
Clé InChI
RTKIYFITIVXBLE-WKWSCTOISA-N
Description générale
Trichostatin A is a compound of primary hydroxamic acid.[1]
Application
Trichostatin A, ready-made solution has been used:
- as a histone deacetylase inhibitor to study its effect on transcriptome changes by stem cell testing[2]
- to inhibit histone deacetylase (HDAC) class I, II, or III in primary pituitary cell cultures and to investigate insulin control of endogenous human growth hormone gene (hGH)[3]
- to treat cells for the HDAC inhibition experiments[4]
Actions biochimiques/physiologiques
Trichostatin A (TSA) is a Streptomyces metabolite, which specifically inhibits mammalian histone deacetylase at a nanomolar concentration and causes accumulation of highly acetylated histone molecules in mammalian cells. For that reason, trichostatin A is a tool to study the consequences of histone acetylation in vivo. Trichostatin A induces cell differentiation, cell cycle arrest, reversal of transformed cells morphology, and apoptosis and is able to modulate transcription. TSA has been used to establish a new cloning technique, which increases the success rates for mouse cloning.
Trichostatin A is a Streptomyces metabolite, which specifically inhibits mammalian histone deacetylase.
Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Les clients ont également consulté
Bioprobes: Biochemical Tools for Investigating Cell Function, 11, 2104-2104 (2012)
Barbara Wójcikowska et al.
Frontiers in plant science, 9, 1353-1353 (2018-10-03)
Auxin is an important regulator of plant ontogenies including embryo development and the exogenous application of this phytohormone has been found to be necessary for the induction of the embryogenic response in plant explants that have been cultured in vitro.
Negative regulation of human growth hormone gene expression by insulin is dependent on hypoxia-inducible factor binding in primary non-tumor pituitary cells
Vakili H, et al.
The Journal of Biological Chemistry, 287(40), 33282-33292 (2012)
Zn(II)-dependent histone deacetylase inhibitors: suberoylanilide hydroxamic acid and trichostatin A.
Rachel Codd et al.
The international journal of biochemistry & cell biology, 41(4), 736-739 (2008-08-30)
Suberoylanilide hydroxamic acid (SAHA, vorinostat, Zolinza) and trichostatin A (TSA) are inhibitors of the Zn(II)-dependent class I and class II histone deacetylases (HDACs), which are enzymes that operate in concert with histone acetyltransferases (HATs) to regulate the acetylation status of
Christophe Guilluy et al.
Nature cell biology, 16(4), 376-381 (2014-03-13)
Mechanical forces influence many aspects of cell behaviour. Forces are detected and transduced into biochemical signals by force-bearing molecular elements located at the cell surface, in adhesion complexes or in cytoskeletal structures. The nucleus is physically connected to the cell
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