810601P
Avanti
16:0-5 Doxyl PC
Avanti Research™ - A Croda Brand 810601P, powder
Synonyme(s) :
1-palmitoyl-2-stearoyl-(5-doxyl)-sn-glycero-3-phosphocholine
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About This Item
Formule empirique (notation de Hill) :
C46H90N2O10P
Numéro CAS:
Poids moléculaire :
862.19
Numéro MDL:
Code UNSPSC :
41141825
Nomenclature NACRES :
NA.25
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Produits recommandés
Essai
>99% (TLC)
Forme
powder
Conditionnement
pkg of 1 × 1 mg (810601P-1mg)
Fabricant/nom de marque
Avanti Research™ - A Croda Brand 810601P
Type de lipide
ESR probes
phospholipids
Conditions d'expédition
dry ice
Température de stockage
−20°C
Description générale
Avanti′s nitroxide spin product listing is a group of compounds designed to act as membrane probes. A variety of positions down the hydrophobic chain are labeled with the nitroxide functional groups to allow probing the membrane at various depths. These compounds have been synthesized from 1-palmitoyl-2-hydroxy-sn-glycerol-3-phosphocholine with the product being purified by column chromatography. Various n-doxyl phosphocholines have been recently used as biophysical tools to elucidate membrane trafficking with phosphatidylinositol transfer proteins and as fluorescent quenchers in lipid bilayer structural studies.[1][2]
Phosphatidylcholine (PC), a strong bilayer-forming lipid is the most common phospholipid in mammalian membranes.[3] The excretory and secretory products of helminths has a small hapten-like portion called phosphorylcholine (PC).[4] The 5th carbon of the sn-2 stearic acid chain of 1-palmitoyl-2-stearoyl-(5-doxyl)-sn-glycero-3-phosphocholine analog has a Doxyl PC, a spin probe attached to it covalently.[5]
Application
16:0-5 Doxyl PC may be used:
- as a component in virus-like large unilamellar vesicles (VL LUVs) to quench 4-chloro-7-nitrobenz-2-oxa-1,3-diazole (NBD) fluorescence emission[6]
- in the preparation of multi-lamellar vesicles (MLVs) as a site-specific quencher to perform fluorescence quenching studies[7]
- in the preparation of spin-labelled multi-lamellar vesicles (MLVs)[8]
Actions biochimiques/physiologiques
Phosphatidylcholine (PC) lowers the levels of cholesterol and triglycerides.[9]
Conditionnement
5 mL Clear Glass Sealed Ampule (810601P-1mg)
Notes préparatoires
Product use: To prevent aggregation, prepare water-based solutions of 2 mM stock solutions of n-DOXYL PCs and store in plastic. Dilute stock solutions to 0.03- 0.1 mM solutions for EPR studies.[10] For liposome preparations in fluorescent quenching measurements, dissolve the doxyl lipid in 150 μl absolute ethanol for a concentration of 40.3 mM [1], Additional supplemental information.
Informations légales
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Souvent commandé avec ce produit
Code de la classe de stockage
11 - Combustible Solids
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Host defenses to helminths
Clinical Immunology, 367-377 (2013)
The Membranes of Cells (2016)
Ultra-stable temperature control in EPR experiments: thermodynamics of gel-to-liquid phase transition in spin-labeled phospholipid bilayers and bilayer perturbations by spin labels
Alaouie AM, et. al.
Journal of Magnetic Resonance, 182, 229-238 (2006)
Tatyana I Smirnova et al.
Biophysical journal, 92(10), 3686-3695 (2007-02-28)
Sec14p promotes the energy-independent transfer of either phosphatidylinositol (PtdIns) or phosphatidylcholine (PtdCho) between lipid bilayers in vitro and represents the major PtdIns/PtdCho transfer protein in the budding yeast Saccharomyces cerevisiae. Herein, we employ multi-frequency high-field electron paramagnetic resonance (EPR) to
Jihong Bai et al.
Nature structural & molecular biology, 11(1), 36-44 (2004-01-14)
Synaptotagmin-1 (syt), the putative Ca2+ sensor for exocytosis, is anchored to the membrane of secretory organelles. Its cytoplasmic domain is composed of two Ca2+-sensing modules, C2A and C2B. Syt binds phosphatidylinositol 4,5-bisphosphate (PIP2), a plasma membrane lipid with an essential
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