808598

CLAmP

• Synonyme(s) : N-Methoxy-N-methyl-1H-pyrrole-1-carboxamide, Heller-Sarpong Reagent
• Formule empirique (notation de Hill): C₇H₁₀N₂O₂
• Poids moléculaire : 154.17
• Code UNSPSC : 12352000
• ID de substance PubChem : 329769111

Propriétés

• Forme: liquid
• Indice de réfraction: n/D 1.510
• Densité: 1.126 g/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C(N(OC)C)N1C=CC=C1
• InChI: 1S/C7H10N2O2/c1-8(11-2)7(10)9-5-3-4-6-9/h3-6H,1-2H3
• Clé InChI: NLSJGNBOCVXWHS-UHFFFAOYSA-N

Description

Application

The CLAmP (Carbonyl Linchpin N, O-dimethylhydroxylamine pyrrole) reagent, reported by Sarpong and Heller, is a useful building block for the efficient synthesis of unsymmetrical ketones. CLAmP shows high versatility based on compatibility with both highly reactive, thermally unstable nucleophiles as well as less reactive stable nucleophiles. It reacts with Grignard reagents to form the corresponding Weinreb amides.

Autres remarques

One-pot Unsymmetrical Ketone Synthesis Employing a Pyrrole-Bearing Formal Carbonyl Dication Linchpin Reagent

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): 230.0 °F
• Point d'éclair (°C): 110 °C