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710806

Sigma-Aldrich

18-Hydroxycorticosterone

97% (CP)

Synonyme(s) :

4-Pregnene-11β,18,21-triol-3,20-dione

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About This Item

Formule empirique (notation de Hill):
C21H30O5
Numéro CAS:
561-65-9
Poids moléculaire :
362.46
Numéro Beilstein :
2631066
Numéro CE :
209-221-9
Numéro MDL:
MFCD00042685
Code UNSPSC :
12352211
ID de substance PubChem :
329763011
Nomenclature NACRES :
NA.24

Pureté

97% (CP)

Forme

powder

Technique(s)

mass spectrometry (MS): suitable

Température de stockage

−20°C

Chaîne SMILES 

O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(CO)[C@@]3([H])CC[C@]4([H])C(CO)=O)=C1

InChI

1S/C21H30O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,14-17,19,22-23,25H,2-7,9-11H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1

Clé InChI

HFSXHZZDNDGLQN-ZVIOFETBSA-N

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Catégories apparentées

Conditionnement

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.
To best serve customer requests, each order is packaged and shipped on demand approximately 2 weeks after receipt of an order. If you have questions regarding availability and price, please contact the Stable Isotope Customer Service Group at 937-859-1808 (1-800-448-9760 for US & Canada) or email us at isosales@sial.com.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Mei-Chuan Chen et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 801(2), 347-353 (2004-01-31)
The analysis of corticosterone in mouse blood serum (metabolic-stress experiment) and 17-hydroxycorticosterone in human urine (exercise-stress experiment) samples by means of capillary electrophoresis/UV absorbance in conjunction with online sample concentration techniques is described. The use of normal MEKC had an
M K Birmingham et al.
Endocrine research, 24(3-4), 595-599 (1999-01-15)
A simple semantic differential test was administered twice daily and urinary hormones measured as described previously . The subjects included the patient and two controls, one of whom experienced premenstrual physical, but not mental, discomfort. The test scores of the
P Vecsei et al.
Clinical chemistry, 28(3), 453-456 (1982-03-01)
For distinguishing primary aldosteronism from essential hypertension, we use simple direct radioimmunoassays for "aldosterone" (aldosterone and other materials that react with the antibody to aldosterone) and "18-hydroxycorticosterone" (similarly) in unprocessed urine. Patients with primary aldosteronism have high values for "aldosterone."
M Peter et al.
The Journal of clinical endocrinology and metabolism, 80(5), 1622-1627 (1995-05-01)
Aldosterone (Aldo), the most potent mineralocorticoid, is synthesized in the adrenal zona glomerulosa, requiring 11 beta-hydroxylation of 11-deoxycorticosterone (DOC) to form corticosterone (B), hydroxylation at position C18 to form 18-hydroxycorticosterone (18-OHB), and finally oxidation at position C18. There is a
C E Gomez-Sanchez et al.
The Journal of clinical endocrinology and metabolism, 67(2), 322-326 (1988-08-01)
The human adrenal gland can metabolize cortisol to yield steroids oxygenated at the 18 position in a series of reactions similar to those by which corticosterone is converted to 18-hydroxycorticosterone and aldosterone and perhaps catalyzed by the same enzyme. These
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