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114715

Sigma-Aldrich

Phenylhydrazine hydrochloride

≥99%

Synonyme(s) :

Phenylhydrazinium chloride

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5 G
17,10 $
100 G
257,00 $
500 G
1 120,00 $

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5 G
17,10 $
100 G
257,00 $
500 G
1 120,00 $

About This Item

Formule linéaire :
C6H5NHNH2 · HCl
Numéro CAS:
59-88-1
Poids moléculaire :
144.60
Beilstein:
3594958
Numéro CE :
200-444-7
Numéro MDL:
MFCD00012924
Code UNSPSC :
12352100
ID de substance PubChem :
24847191
Nomenclature NACRES :
NA.22
Forme:
solid
Essai:
≥99%

17,10 $

En stockDétails

Devis pour commande en gros

Niveau de qualité

200

Essai

≥99%

Forme

solid

Pf

250-254 °C (dec.) (lit.)

Solubilité

H2O: soluble 50 mg/mL

Groupe fonctionnel

hydrazine

Chaîne SMILES 

Cl[H].NNc1ccccc1

InChI

1S/C6H8N2.ClH/c7-8-6-4-2-1-3-5-6;/h1-5,8H,7H2;1H

Clé InChI

JOVOSQBPPZZESK-UHFFFAOYSA-N

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Application

Phenylhydrazine hydrochloride is used in the examination of tyrosine phosphorylation of Janus protein tyrosine kinase (JAKs) in the EPO-responsive normal erythroblastoid cells of anemic mice[1].

Actions biochimiques/physiologiques

Phenylhydrazine hydrochloride causes acute hemolysis when injected intraperitoneally in to wild-type and Hp and Hx single-null mice[2]. It suppresses the horseradish peroxide (HRP) residual activity in tissue sections of animals[3].

Notes préparatoires

50 gm of Phenylhydrazine hydrochloride dissolves in 1 mL of water to yield a clear, very faint yellow solution.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

Skull and crossbonesHealth hazardEnvironment
GHS06,GHS08,GHS09

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Carc. 1B - Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 1

Code de la classe de stockage

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number
BCCJ6929
BCCJ6913
BCCJ6912
BCCD8581
BCCD8580

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Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

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Sigma-Aldrich

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Clinton Stewart et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 22(1), 612-629 (2019-12-10)
Cyclophosphamide is widely used to treat children with medulloblastoma; however, little is known about its brain penetration. We performed cerebral microdialysis to characterize the brain penetration of cyclophosphamide (130 mg/kg, IP) and its metabolites [4-hydroxy-cyclophosphamide (4OH-CTX) and carboxyethylphosphoramide mustard (CEPM)]
Phenylhydrazine as inhibitor of horseradish peroxidase for use in immunoperoxidase procedures.
W Straus
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 20(11), 949-951 (1972-11-01)
Emanuela Tolosano et al.
Blood, 100(12), 4201-4208 (2002-10-24)
Intravascular hemolysis is associated with several pathologic conditions that include hemoglobinopathies, trauma, malaria, and bacterial infections. Among plasma-protective proteins against oxidative damage caused by red blood cell rupture, haptoglobin and hemopexin are thought to play a crucial role. Haptoglobin and
Y Yamamura et al.
Molecular and cellular biology, 18(3), 1172-1180 (1998-03-06)
Abnormal erythropoietin (EPO)-independent cell growth is induced after infection of erythroid progenitor cells with a polycythemic strain of Friend virus (FVp). Binding of its Env-related glycoprotein (gp55) to the EPO receptor (EPOR) mimics the activation of the EPOR with EPO.
Jason S Nagati et al.
PloS one, 14(11), e0225105-e0225105 (2019-11-15)
The response to environmental stresses by eukaryotic organisms includes activation of protective biological mechanisms, orchestrated in part by transcriptional regulators. The tri-member Hypoxia Inducible Factor (HIF) family of DNA-binding transcription factors include HIF-2, which is activated under conditions of oxygen
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Questions

1–4 of 4 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Can we store aliquots of PHZ (dissolved in PBS) in -20? How long does it remain stable? Thanks!

    1 answer

    1. This product has not been evaluated for stability in solution. Phenylhydrazine HCl solutions may decompose when exposed to light and air. There are commercially available solutions in water that are packaged in amber glass and have an approximate shelf life of 1 year at room temperature, according to manufacturers. Note that this information has not been validated.

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  4. Como puedo saber la fecha de caducidad si no aparece en el CoA?

    1 answer

    1. This product does not contain an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one year warranty from the date of shipment. For more information you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.

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