PHL85771

Securinine

phyproof^® Reference Substance

• Fórmula empírica (Notação de Hill): C₁₃H₁₅NO₂
• Número CAS: 5610-40-2
• Peso molecular: 217.26
• Número MDL: MFCD00078775
• Código UNSPSC: 41116107
• NACRES: NA.24

Propriedades

• grau: primary reference standard
• linha de produto: phyproof^® Reference Substance
• Ensaio: ≥90.0% (HPLC)
• Formulário: solid
• fabricante/nome comercial: PhytoLab
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O=C1O[C@@]23C[C@@H](C=CC2=C1)N4CCCC[C@H]34
• InChI: 1S/C13H15NO2/c15-12-7-9-4-5-10-8-13(9,16-12)11-3-1-2-6-14(10)11/h4-5,7,10-11H,1-3,6,8H2/t10-,11-,13+/m1/s1
• chave InChI: SWZMSZQQJRKFBP-WZRBSPASSA-N

Descrição

Descrição geral

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Ações bioquímicas/fisiológicas

Securinine is a GABAA receptor antagonist which has been found to increase p73 protein expression

Securinine is an alkaloid widely in traditional folk medicine. Long known as a GABAA antagonist, securinine was recently found to up-regulate p53 protein and to modulate the related family member p73 protein in a p53-dependent fashion, inducing p73 in the HCT116 p53(-) cells and down-regulating it in the p53(+) cells. Induction of proapoptotic protein p73 only in p53 cells could be used to target cancer cells preferentially. Securinine has been found to induce p53-independent, p73-dependent apoptosis in RKO colon cancer cells.

Informações legais

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H301
• Declarações de precaução: P264 - P270 - P301 + P310 - P405 - P501
• Classificações de perigo: Acute Tox. 3 Oral
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3