T8276

Anti-TRPC1 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• Sinônimo(s): Trpc1 Antibody, Trpc1 Antibody - Anti-TRPC1 antibody produced in rabbit, Anti-Transient receptor potential cation channel, subfamily C, member 1
• Número MDL: MFCD02686004
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: lyophilized powder
• reatividade de espécies: rat
• técnica(s): immunohistochemistry: suitable; western blot (chemiluminescent): suitable
• nº de adesão UniProt: Q9QX01
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... TRPC1(7220) ; mouse ... Trpc1(22063) ; rat ... Trpc1(89821)

Descrição

Descrição geral

Transient receptor potential cation channel subfamily C member 1 (TRPC1) is encoded by the gene mapped to human chromosome 3q22-24. The encoded protein is a member of the transient receptor potential (TRP) superfamily of cation channels and is distributed in both glomeruli and glomerular mesangial cells.

Imunogênio

Synthetic protein corresponding to amino acids 557-571 of human TRPC1 (GenBank^® Accession No. P48995). The epitope is identical in mouse and rat and highly homologous in bovine and Xenopus.

Ações bioquímicas/fisiológicas

Transient receptor potential cation channel subfamily C member 1 (TRPC1) facilitates Ca²⁺ entry upon store depletion in a variety of cell types by forming a multimeric complex with other TRPCs. The encoded protein is implicated in the odontoblast-like differentiation of human dental pulp cells (hDPCs). Mutation in the gene is associated with the development type 2 diabetes mellitus (T2D). Decreased expression of the gene leads to hepatocellular carcinoma cell proliferation and thus, TRPC1 can be considered as a potential therapeutic target for hepatocellular carcinoma.

forma física

Lyophilized at 0.3 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

Informações legais

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Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Pictogramas: GHS06,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H301 + H311,H411
• Declarações de precaução: P273 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P391 - P501
• Classificações de perigo: Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Chronic 2
• Perigos de suplementos: EUH032
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges