T1327
Tissue Inhibitor of Metalloproteinase-3 human
recombinant, expressed in NSO cells, >95% (SDS-PAGE)
Sinônimo(s):
TIMP-3
Faça loginpara ver os preços organizacionais e de contrato
Selecione um tamanho
10 μG
R$ 5.384,00
R$ 5.384,00
Check Cart for Availability
Selecione um tamanho
Alterar visualização
10 μG
R$ 5.384,00
About This Item
R$ 5.384,00
Check Cart for Availability
Produtos recomendados
fonte biológica
human
Nível de qualidade
recombinante
expressed in NSO cells
Ensaio
>95% (SDS-PAGE)
Formulário
lyophilized powder
peso molecular
apparent mol wt ~30 kDa
técnica(s)
inhibition assay: suitable
nº de adesão UniProt
temperatura de armazenamento
−20°C
Informações sobre genes
human ... TIMP3(7078)
Procurando produtos similares? Visita Guia de comparação de produtos
Descrição geral
Tissue inhibitor of metalloproteinases 3 (TIMP3) is localized in the extracellular matrix (ECM) of epithelial cells associated with kidneys, eyes and lungs.[1] It is majorly secreted in retinal pigment epithelium (RPE).[2] TIMP3 gene is mapped to human chromosome 22q12.3[1] and is a CLOCK-dependent diurnal gene.[3] TIMP proteins display a three-lobed structure and have conserved cysteine residues.[2]
Ações bioquímicas/fisiológicas
The TIMPs are endogenous inhibitors of the matrix metalloproteinases (MMPs). TIMP-3 inhibits ADAM-17 (TACE) at nanomolar concentrations and also inhibits other metalloproteinases (sheddases) that mediate the shedding of soluble receptors and other proteins from the surface of cells.
Tissue inhibitor of metalloproteinases 3 (TIMP3) is a matrix metalloproteinase inhibitor.[3] TIMP proteins comprise the N-terminal region, which aids in the matrix metalloproteinase interaction. The C-terminal region is crucial for extracellular matrix (ECM) interaction.[2] Elevated expression of TIMP3 favors apoptosis in cancer types.[3] Its interaction with the vascular endothelial growth factor (VEGFR-2) leads to the regulation of angiogenesis.[1] TIMP3 also aids in protection against ultra-violet (UV)-induced cellular responses.[3] Missense mutations in the TIMP3 gene are implicated in Sorsby′s fundus dystrophy (SFD).[1] Mutations in the TIMP3 gene also leads to increased accumulation of the protein resulting in the thickening of the Bruch membrane. This, in turn, reduces membrane permeability towards nutrients and metabolites.[2]
forma física
Lyophilized from a 0.2 μm filtered solution in 25 mM Tris and 0.15 M sodium chloride, pH 7.5.
Nota de análise
The biological activity is measured by its ability to inhibit human MMP-2 hydrolysis of a peptide substrate.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
dust mask type N95 (US), Eyeshields, Gloves
Escolha uma das versões mais recentes:
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Daniel Ardeljan et al.
European journal of human genetics : EJHG, 21(10), 1152-1157 (2013-02-21)
Age-related macular degeneration (AMD) is a leading cause of irreversible central visual loss in the elderly. A recent genome-wide association studies (GWAS) reported that rs9621532 near the tissue inhibitor of metalloproteinase 3 (TIMP3)/synapsin III (SYN3) region of 22q12.3 is associated
Sunyoung Park et al.
International journal of molecular sciences, 20(4) (2019-02-20)
The human skin is the outermost physical barrier and has its own circadian machinery that works either cooperatively with the central clock, or autonomously. Circadian rhythms have been observed in many functions related to epidermal homeostasis including hydration and inflammation
Ruth Appeltant et al.
Animal science journal = Nihon chikusan Gakkaiho, 88(9), 1279-1290 (2017-01-27)
In vitro maturation (IVM) in serum causes hampered expansion of porcine cumulus-oocyte complexes (COCs) due to excessive alpha
K J Leco et al.
The Journal of biological chemistry, 269(12), 9352-9360 (1994-03-25)
We have isolated cDNA clones corresponding to a novel mouse metalloproteinase inhibitor. Five overlapping cDNA clones contain most of the information for a prominent 4.5-kilobase transcript that was detected in RNA from mouse fibroblasts and adult tissues. Sequence analysis revealed
S M Silbiger et al.
Gene, 141(2), 293-297 (1994-04-20)
Proteins of the tissue inhibitor of metalloproteinase (TIMP) family bind and inactivate matrix metalloproteinases such as collagenases and gelatinases. We report the cloning and sequencing of cDNAs encoding a novel human TIMP, which we designated TIMP-3, the third member of
Active Filters
Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.
Entre em contato com a assistência técnica
