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T1126

Sigma-Aldrich

Thyroglobulin from porcine thyroid gland

powder

Sinônimo(s):

TG human

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About This Item

Número CAS:
Número CE:
Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.61

fonte biológica

Porcine thyroid

forma

powder

peso molecular

~670 kDa

composição

Iodine, ≥0.3%

análise de nitrogênio

14.0-17.5% total

técnica(s)

protein purification: suitable

cinzas

≤4%

pI 

4.58

nº de adesão UniProt

temperatura de armazenamento

−20°C

Informações sobre genes

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Ações bioquímicas/fisiológicas

Thyroglobulin has been shown to regulate the transcription of iodide porters including sodium iodide symporter and pendrin.
Thyroglobulin is a major protein involved with iodine metabolism. It consists of an iodine-containing protein that is stored in the thyroid gland and is converted into circulating thyroxines when the thyroid is stimulated by TSH (Thyroid Stimulating Hormone) from the pituitary. Thyroglobulin is often used as a carrier protein for the production of antibodies. Its advantage as a carrier protein comes from its large number of tyrosine residues that can be used for conjugation using the diazo reaction.

Outras notas

Electrophoretically heterogeneous.

Nota de preparo

When reconstituted in water (20 mg/ml), a turbid solution with some insolubles is observed.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)


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Sanathana Konugolu Venkata Sekar et al.
Scientific reports, 8(1), 10015-10015 (2018-07-04)
Thyroid plays an important role in the endocrine system of the human body. Its characterization by diffuse optics can open new path ways in the non-invasive diagnosis of thyroid pathologies. Yet, the absorption spectra of tyrosine and thyroglobulin-key tissue constituents
Yang Li et al.
International journal of endocrinology, 2021, 9439344-9439344 (2021-08-24)
45 healthy and adult female SD rats were randomly divided into three groups: normal control group, EAT model group, and selenium yeast supplement EAT group. The EAT model rats were induced by subcutaneous injection of porcine thyroglobulin and fed with
Tanuza Nazmul et al.
Microbiology and immunology, 67(7), 334-344 (2023-05-30)
We first investigated the interactions between several algae-derived lectins and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We created lectin columns using high-mannose (HM)-type glycan-specific lectins OAA and KAA-1 or core fucose-specific lectin hypninA-2 and conducted binding experiments with SARS-CoV-2. The
Kotaro Kelley et al.
Nature communications, 13(1), 1857-1857 (2022-04-08)
Cryo-FIB/SEM combined with cryo-ET has emerged from within the field of cryo-EM as the method for obtaining the highest resolution structural information of complex biological samples in-situ in native and non-native environments. However, challenges remain in conventional cryo-FIB/SEM workflows, including
L D Kohn et al.
Trends in endocrinology and metabolism: TEM, 12(1), 10-16 (2001-01-04)
Iodide transport by thyrocytes involves porters on the apical and basal surfaces of the cell facing the follicular lumen and bloodstream, respectively. Recent work identifies pendrin as an apical porter and shows that follicular thyroglobulin is a transcriptional regulator of

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