SRP5220
KAT8 (2-467), GST tagged human
recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinônimo(s):
FLJ14040, KAT8, MOF, MYST1, hMOF
Faça loginpara ver os preços organizacionais e de contrato
Selecione um tamanho
20 μG
R$ 2.038,00
Selecione um tamanho
Alterar visualização
20 μG
R$ 2.038,00
About This Item
Produtos recomendados
fonte biológica
human
recombinante
expressed in baculovirus infected Sf9 cells
Ensaio
≥70% (SDS-PAGE)
Formulário
buffered aqueous glycerol solution
peso molecular
~83 kDa
nº de adesão NCBI
aplicação(ões)
cell analysis
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
human ... KAT8(84148)
Descrição geral
Lysine acetyltransferase 8 (KAT8) or MYST histone acetyltransferase 1 (MYST1) is a signaling protein that belongs to the MYST family of histone acetyl transferases (HATs). MYST1 has a chromodomain that is involved in protein-protein interactions and targeting transcriptional regulators to the chromatin.[1][2]
Ações bioquímicas/fisiológicas
Lysine acetyltransferase 8 (KAT8) or MYST histone acetyltransferase 1 (MYST1) was originally isolated as a human immunodeficiency virus-1 (HIV-1) TAT-interactive protein, which plays important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and non-histone proteins. MYST1 is also involved in ataxia-telangiectasia mutated (ATM) function. It acetylates histone 4-lysine 16 (H4K16). The protein is a modulator of embryonic stem cells and an epigenetic regulator. It has been associated with gastric carcinoma.[3][1][4]
forma física
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Nota de preparo
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Escolha uma das versões mais recentes:
Certificados de análise (COA)
Lot/Batch Number
Não está vendo a versão correta?
Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
The Histone Acetyltransferase MOF Promotes Induces Generation of Pluripotent Stem Cells.
Mu X
Cellular Reprogramming, 17(4), 259-267 (2015)
Mof (MYST1 or KAT8) is essential for progression of embryonic development past the blastocyst stage and required for normal chromatin architecture.
Thomas T
Molecular and Cellular Biology, 28(16), 5093-5105 (2008)
MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice.
Gupta A
Cell Reports, 8(1), 177-189 (2014)
Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma.
Zhu L
International Journal of Oncology, 46(6), 2535-2545 (2015)
K C Neal et al.
Biochimica et biophysica acta, 1490(1-2), 170-174 (2000-04-29)
We have identified a novel human gene product, hMOF, which exhibits significant similarity to the Drosophila dosage compensation regulator, MOF. A recombinant C-terminal portion of hMOF has histone acetyltransferase activity directed toward histones H3, H2A and H4, a specificity characteristic
Active Filters
Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.
Entre em contato com a assistência técnica
