SRP4928
Lipocalin-2 human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Sinônimo(s):
25 kDa α-2-microglobulin-related subunit of MMP-9, Lipocalin-2, NGAL, Neutrophil gelatinase-associated lipocalin, Oncogene 24p3, p25
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About This Item
Código UNSPSC:
12352200
NACRES:
NA.32
Produtos recomendados
fonte biológica
human
recombinante
expressed in E. coli
Ensaio
≥95% (HPLC)
≥95% (SDS-PAGE)
Formulário
lyophilized
peso molecular
~20 kDa
embalagem
pkg of 50 μg
técnica(s)
activity assay: suitable
Impurezas
endotoxin, tested
nº de adesão NCBI
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
Informações sobre genes
human ... LCN2(3934)
Descrição geral
Research area: Cell signaling. The gene LCN2 (lipocalin 2) is mapped to human chromosome 9q34.[1] LCN2, a secreted glycoprotein, is an adipokine.[2][3] It is expressed by many cells, such as respiratory and intestinal epithelial cells, endothelial cells, renal tubular cells, and cardiomyocytes. LCN2 belongs to the lipocalin family.[4] LCN2 consists of the lipid binding domain that binds to small hydrophobic molecules and the ligand binding cavity that binds to bacterial and mammalian proteins called siderophores.[5]
Aplicação
Ações bioquímicas/fisiológicas
LCN2 (lipocalin 2) potentially connects obesity and its related adipose inflammation.[2][3] LCN2 has also been implicated in a variety of processes including cell differentiation, tumorigenesis, and apoptosis.[4] It is an early marker of acute kidney injury, cardiovascular diseases, lupus nephritis, and intestinal inflammation.[5] LCN2 is upregulated in humans with heart failure.[4] It can associate with MMP9 (matrix metalloproteinase-9) and controls its stability.[8][2] Changes in the expression of LCN2 are associated with many cancers, including breast, colorectal, pancreatic, ovarian, gastric, thyroid, ovarian, bladder, and kidney cancers.[2]LCN2 acts as a pleiotropicmolecule and plays a role in several pathophysiological and physiologicalactivities including immune response, inflammation, metabolic homeostasis, andinfection.[5]
forma física
Lyophilized with no additives.
Reconstituição
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration 0.1-1 mg/mL. The solution can then be further diluted to other aqueous solutions.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Biao Wang et al.
Shock (Augusta, Ga.), 44(3), 234-238 (2015-05-27)
This study examines the clinical utility of increased neutrophil gelatinase-associated lipocalin (NGAL) as an indicator of mortality and multiple organ dysfunction syndrome (MODS) in severe sepsis and septic shock. We designed a prospective cohort study in an intensive care unit
A bimetallic PtPd hybrid nanostructure-amplified enzyme-free conductometric immunoassay for lipocalin-2 in renal cell carcinoma on an interdigitated micro-comb electrode.
Huang C, et al.
Analytical Methods, 12(15), 1988-1994 (2020)
The pancreatic expression database: recent extensions and updates.
Dayem Ullah AZ
Nucleic Acids Research, 42, D944-D949 (2014)
Guoliang Wang et al.
International journal of biological sciences, 10(7), 798-806 (2014-08-01)
A key feature of pulmonary hypertension (PH) is the remodeling of small pulmonary arteries due to abnormal pulmonary artery smooth muscle cell (PASMC) proliferation and resistance to apoptosis. However, the cellular mechanisms underlying how PASMCs in the pathological condition of
Plasma levels of neutrophil gelatinase-associated lipocalin in children with heart failure.
Tawfeek MS
Therapeutic Advances in Cardiovascular Disease, 10, 30-36 (2016)
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