SRP4542

FGF-19 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

• Sinônimo(s): FGF19, FGFJ, fibroblast growth factor 19
• Código UNSPSC: 12352202
• NACRES: NA.32

Propriedades

• fonte biológica: human
• recombinante: expressed in E. coli
• Ensaio: ≥95% (SDS-PAGE)
• Formulário: lyophilized
• potência: 50-200 ng/mL
• peso molecular: ~21.8 kDa
• embalagem: pkg of 25 μg
• condição de armazenamento: avoid repeated freeze/thaw cycles
• Impurezas: endotoxin, tested
• nº de adesão NCBI: NM_005117
• nº de adesão UniProt: O95750
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• Informações sobre genes: human ... FGF19(9965)

Descrição

Descrição geral

Fibroblast growth factor-19 (FGF-19) is an ileum-derived polypeptide hormone and a high affinity heparin-dependent ligand for fibroblast growth factor receptor 4 (FGFR4). It is part of the hormone-like FGF family. The gene encoding FGF-19 is localized on human chromosome 11q13.3. Recombinant human FGF-19 is a 21.8kDa protein containing 195 amino acid residues.

Ações bioquímicas/fisiológicas

Fibroblast growth factor-19 (FGF-19) is involved in the gut-liver signaling pathway and modulation of bile acid synthesis. Once secreted, it binds to the hepatic fibroblast growth factor receptor 4 (FGFR4)/Klotho-β cell-surface receptor complex and activates it. FGF-19 promotes glycogen synthesis, protein synthesis and lipid metabolism.

forma física

Lyophilized from 5 mM Tris, pH 7.6 plus 75 mM NaCl. The protein may appear as a haze or film, which you may not see at the bottom of the vial.

Reconstituição

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 0.1 to 1.0 μg/μL. This solution can then be diluted into other aqueous buffers.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable