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SRP3215

Sigma-Aldrich

JE/MCP-1 (CCL2) from mouse

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Sinônimo(s):

CCL2, JE, MCAF

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About This Item

Código UNSPSC:
12352200
NACRES:
NA.77

fonte biológica

mouse

recombinante

expressed in E. coli

Ensaio

≥98% (HPLC)
≥98% (SDS-PAGE)

forma

lyophilized

peso molecular

13.8 kDa

embalagem

pkg of 10 μg

técnica(s)

cell culture | mammalian: suitable

Impurezas

<0.1 EU/μg endotoxin, tested

cor

white to off-white

nº de adesão UniProt

P10148

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

Informações sobre genes

mouse ... CCL2(20296)

Descrição geral

The monocyte chemoattractant proteins (MCPs) belong to the C-C chemokine family, and signal through C-C motif chemokine receptor-2 (CCR2) and, with the exception of MCP-1 or chemokine (C-C motif) ligand 2 (CCL2) , other CCR receptors. The MCP family cross reacts across species. The gene encoding CCL2 is localized on mouse chromosome 11. Recombinant murine JE is a 13.8kDa protein containing 125 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Ações bioquímicas/fisiológicas

The monocyte chemoattractant proteins (MCPs) chemo attract and activate monocytes, activated T cells, basophils, natural killer (NK) cells and immature dendritic cells. It has a role in the survival and proliferation of microglia. Chemokine (C-C motif) ligand 2 (CCL2) has been shown to activate GTPases like cell division control protein 42 (CDC42) and Ras-related C3 botulinum toxin substrate 1 (Rac1).

Sequência

QPDAVNAPLT CCYSFTSKMI PMSRLESYKR ITSSRCPKEA VVFVTKLKRE VCADPKKEWV QTYIKNLDRN QMRSEPTTLF KTASALRSSA PLNVKLTRKS EANASTTFST TTSSTSVGVT SVTVN

forma física

Lyophilized with no additives.

Reconstituição

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Evidence for a cluster of genes on chromosome 17q11-q21 controlling susceptibility to tuberculosis and leprosy in Brazilians.
Jamieson SE
Genes and Immunity, 5(1), 46-57 (2004)
Vascular Stem/Progenitor Cell Migration Induced by Smooth Muscle Cell-Derived Chemokine (C-C Motif) Ligand 2 and Chemokine (C-X-C motif) Ligand 1 Contributes to Neointima Formation.
Yu B
Stem Cells, 34(9), 2368-2380 (2016)
Rollins, R.J., et al.
Cytokine Reference, 1145-1160 (2001)
Magdaléna Vaváková et al.
Scientific reports, 13(1), 10559-10559 (2023-06-30)
Salt-inducible kinase 2 (SIK2) is highly expressed in white adipocytes, but downregulated in individuals with obesity and insulin resistance. These conditions are often associated with a low-grade inflammation in adipose tissue. We and others have previously shown that SIK2 is

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