SRP3214

I-TAC (CXCL11) from mouse

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

• Sinônimo(s): B-R1, CXCL11
• Código UNSPSC: 12352202
• NACRES: NA.32

Propriedades

• fonte biológica: mouse
• recombinante: expressed in E. coli
• Ensaio: ≥98% (HPLC); ≥98% (SDS-PAGE)
• Formulário: lyophilized
• potência: 10.0-100.0 ng/mL
• peso molecular: 9.0 kDa
• embalagem: pkg of 20 μg
• técnica(s): cell culture | mammalian: suitable
• Impurezas: <0.1 EU/μg endotoxin, tested
• cor: white to off-white
• nº de adesão UniProt: Q9JHH5
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• Informações sobre genes: mouse ... CXCL11(56066)

Descrição

Descrição geral

CXCL11 (C-X-C motif chemokine 11), also referred to as I-TAC (interferon-inducible T-cell α chemoattractant), is from to the CXC chemokine family and is an antagonist for CC chemokine receptor 3 (CCR3) and CCR5.[1] CXCL11 was first identified in astrocytes via cDNA sequencing. It can be induced by IFN (interferon)-γ in different cells. CXCL11 interacts with and signals via CXCR3 (C-X-C chemokine receptor type 3).[2]
Recombinant murine I-TAC is a 9.0kDa protein containing 79 amino acid residues including the four highly conserved cysteine residues present in CXC chemokines.

Ações bioquímicas/fisiológicas

CXCL11 (C-X-C motif chemokine 11) is involved in the wound repair in skin cells.[3] CXCL11′s interaction with CXCR3 (C-X-C chemokine receptor type 3) polarizes naive T cells into IL (interleukin)-10^hi Tregs (regulatory T cells, Tr1) and repolarizes CXCR3⁺CD4⁺ EAE (experimental autoimmune encephalomyelitis)-associated effector T cells into IL-10^hi Tregs.[4] CXCL11 also enhances Th2 (T helper 2) response in model leishmaniasis system, and thereby regulates the outcome of the immunological pathway.[1] In mice model, CXCL11 is upregulated in RSV (respiratory syncytial virus) and influenza A infections.[5]

Sequência

FLMFKQGRCL CIGPGMKAVK MAEIEKASVI YPSNGCDKVE VIVTMKAHKR QRCLDPRSKQ ARLIMQAIEK KNFLRRQNM

forma física

Lyophilized with no additives.

Reconstituição

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable