SML3553

STF-1084

≥98% (HPLC)

• Sinônimo(s): ENPP1 inhibitor Compound 15, P-​[2-​[1-​(6,​7-​dimethoxy-​4-​quinazolinyl)​-​4-​piperidinyl]​ethyl]​-phosphonic acid
• Fórmula empírica (Notação de Hill): C₁₇H₂₄N₃O₅P
• Número CAS: 2298390-71-1
• Peso molecular: 381.36
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to beige
• solubilidade: DMSO: 2 mg/mL, clear
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O=P(O)(O)CCC(CC1)CCN1C2=NC=NC3=C2C=C(OC)C(OC)=C3
• InChI: 1S/C17H24N3O5P/c1-24-15-9-13-14(10-16(15)25-2)18-11-19-17(13)20-6-3-12(4-7-20)5-8-26(21,22)23/h9-12H,3-8H2,1-2H3,(H2,21,22,23)
• chave InChI: SNLWMWQNJTVWKD-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

Cell-impermeable, potent, selective, stable and nontoxic competitive inhibitor of ENPP1 that inhibit degradation of extracellular cGAMP under physiological conditions

STF-1084 (ENPP1 inhibitor Compound 15) Is a cell-impermeable, potent, selective, stable and nontoxic competitive inhibitor of ENPP1 (ectonucleotide pyrophosphatase phosphodiesterase 1) that inhibit degradation of extracellular cGAMP under physiological conditions. STF-1084 had no effect on intracellular cGAMP. STF-1084 synergized with IR to significantly delay tumor progression in three triple-negative breast cancer cell lines 4T1-luc mice model.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable