Ponalrestat is an orally available, potent and specific inhibitor of aldehyde reductase 2 (ALR2) that blocks the conversion of glucose to sorbitol. Ponalrestat promotes root elongation through the inhibition of the flavin monooxygenase YUCCA in Arabidopsis.
orally available, potent and specific inhibitor of aldehyde reductase 2 (ALR2)
Chemical research in toxicology, 33(8), 2164-2171 (2020-07-09)
Bile acids (BAs) play essential physiological roles not only by facilitating the absorption and transport of nutrients but also by acting as a complex molecular signaling system. Reduced levels of BAs have been observed in obesity and other metabolic disorders.
Mini reviews in medicinal chemistry, 16(2), 120-162 (2015-09-10)
Diabetes mellitus occurrence has been associated to the modification of the physiological levels of glucose and is often accompanied by several long-term complications, namely neuropathy, nephropathy, retinopathy, cataract, and cardiovascular. Aldose reductase (AR) is an enzyme of aldoketo reductase super-family
The Journal of biological chemistry, 294(52), 19923-19933 (2019-11-17)
Plant development is regulated by both synergistic and antagonistic interactions of different phytohormones, including a complex crosstalk between ethylene and auxin. For instance, auxin and ethylene synergistically control primary root elongation and root hair formation. However, a lack of chemical
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