SML1875

(2S,6S)-Hydroxynorketamine hydrochloride

≥98% (HPLC)

• Sinônimo(s): (2S,6S)-2-Amino-2-(2-chlorophenyl)-6-hydroxy-cyclohexanone hydrochloride, (2S,6S)-HNK hydrochloride
• Fórmula empírica (Notação de Hill): C₁₂H₁₄ClNO₂ · HCl
• Número CAS: 1430202-70-2
• Peso molecular: 276.16
• Código UNSPSC: 12352116
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: powder
• atividade óptica: [α]/D +95 to +115°, c = 1 in H₂O
• controle de medicamentos: regulated under CDSA - not available from Sigma-Aldrich Canada
• condição de armazenamento: desiccated
• cor: white to beige
• solubilidade: H₂O: 25 mg/mL, clear
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: [H]Cl.ClC1=CC=CC=C1[C@](CCC[C@@H]2O)(N)C2=O

Descrição

Ações bioquímicas/fisiológicas

(2S,6S)-Hydroxynorketamine hydrochlorideKetamine is a metabolite associated with increased locomotor activity and motor incoordination.
It has been found that the NMDAR antagonist (R,S)-ketamine must be metabolized to (2S,6S;2R,6R)-hydroxynorketamine (HNK) to have antidepressant effects. The (2R,6R)-HNK enantiomer appears to be the enantiomer most responsible for antidepressant effects, while (2S,6S)-hydroxynorketamine was associated with increased locomotor activity and motor incoordination. (2S,6S)-HNK, was also found to increase the function of the mammalian target of rapamycin (mTOR) 2-fold at 0.05 nM. (2S,6S)-HNK and (2R,6R)-HNK both inhibited intracellular concentrations of D-serine, an endogenous NMDA receptor co-agonist, with IC₅₀ values of 0.18 nM and 0.68 nM, respectively. Neither bind with high affinity to NMDA receptors, with Ki values of 21.19 μM and > 100 μM for (2S,6S)-HNK and (2R,6R)-HNK, respectively.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable