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SML0483

Sigma-Aldrich

DpC

≥98% (HPLC)

Sinônimo(s):

Di-2-pyridylketone-4-cyclohexyl-4-methyl-3-thiosemicarbazone

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About This Item

Fórmula empírica (Notação de Hill):
C19H23N5S
Número CAS:
1382469-39-7
Peso molecular:
353.48
Número MDL:
MFCD22666593
Código UNSPSC:
12352200
ID de substância PubChem:
329825434
NACRES:
NA.77

Ensaio

≥98% (HPLC)

forma

powder

condição de armazenamento

protect from light

cor

white to beige

solubilidade

DMSO: 5 mg/mL (clear solution)

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CN(C1CCCCC1)C(=S)N\N=C(\c2ccccn2)c3ccccn3

InChI

1S/C19H23N5S/c1-24(15-9-3-2-4-10-15)19(25)23-22-18(16-11-5-7-13-20-16)17-12-6-8-14-21-17/h5-8,11-15H,2-4,9-10H2,1H3,(H,23,25)

chave InChI

GNLZNQJBZNOUBM-UHFFFAOYSA-N

Ações bioquímicas/fisiológicas

DpC is an iron-chelating agent.
DpC is an iron-chelating agent. In four separate human pancreatic tumor cell lines, DpC significantly increased the expression and phosphorylation of the growth and metastasis suppressor, N-myc down-stream regulated gene 1 (NDRG1) and the cdk inhibitpr p21CIP1/WAF. DpC completely blocked PANC-1 tumor growth in mouse xenografts.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H301

Declarações de precaução

P264 - P270 - P301 + P310 - P405 - P501

Classificações de perigo

Acute Tox. 3 Oral

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Ye-Xing Xu et al.
Oncology letters, 15(5), 7999-8004 (2018-05-10)
The present study aimed to investigate the antitumor efficacy of di-2-pyridylketone-4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC) and di-2-pyridylketone-4,4,-dimethyl-3-thiosemicarbazone (Dp44mT) on head and neck squamous cell carcinoma (HNSCC) cells. The proliferation and apoptosis of HNSCC cells treated with the iron chelators DpC and Dp44mT were
Zaklina Kovacevic et al.
The Journal of biological chemistry, 291(3), 1029-1052 (2015-11-05)
N-MYC downstream-regulated gene-1 (NDRG1) is a potent growth and metastasis suppressor that acts through its inhibitory effects on a wide variety of cellular signaling pathways, including the TGF-β pathway, protein kinase B (AKT)/PI3K pathway, RAS, etc. To investigate the hypothesis
Ruxing Xi et al.
Molecular pharmacology, 91(5), 499-517 (2017-03-10)
Tumor necrosis factor α (TNFα) plays a vital role in cancer progression as it is associated with inflammation and promotion of cancer angiogenesis and metastasis. The effects of TNFα are mediated by its downstream target, the oncogene lysine-rich CEACAM1 coisolated
Sang Y Lee et al.
Anticancer research, 41(6), 2795-2804 (2021-06-05)
Neuroblastoma is the most common childhood extracranial solid malignancy. Although cancer cells need iron and lipids for active cell division, possible links between iron and lipid metabolism in neuroblastomas have not been studied. We evaluated the levels and association between
Wensheng Liu et al.
Oncotarget, 6(11), 8851-8874 (2015-04-11)
N-myc downstream regulated gene-1 (NDRG1) is a potent metastasis suppressor that plays a key role in regulating signaling pathways involved in mediating cancer cell invasion and migration, including those derived from prostate, colon, etc. However, the mechanisms and molecular targets

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