SML0445

Clemastine fumarate salt

≥98% (HPLC)

• Sinônimo(s): (+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate salt, (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate salt, 1-Methyl-2-[2-(α-methyl-p-chlorobenzhydryloxy)ethyl]pyrrolidine fumarate salt, 1-Methyl-2-[2-(methyl-p-chlorodiphenylmethyloxy)ethyl]pyrrolidine fumarate salt, Meclastine fumarate salt, Mecloprodine
• Fórmula empírica (Notação de Hill): C₂₁H₂₆ClNO · C₄H₄O₄
• Número CAS: 14976-57-9
• Peso molecular: 459.96
• Número CE: 239-055-2
• Número MDL: MFCD00137486
• Código UNSPSC: 12352200
• ID de substância PubChem: 329824727
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Formulário: powder
• atividade óptica: [α]/D +15 to +25°, c = 1 in methanol
• condição de armazenamento: desiccated
• cor: white to beige
• solubilidade: DMSO: 5 mg/mL (clear solution; warmed)
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: OC(=O)\C=C\C(O)=O.CN1CCC[C@@H]1CCO[C@](C)(c2ccccc2)c3ccc(Cl)cc3
• InChI: 1S/C21H26ClNO.C4H4O4/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2;5-3(6)1-2-4(7)8/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t20-,21-;/m1./s1
• chave InChI: PMGQWSIVQFOFOQ-YKVZVUFRSA-N
• Informações sobre genes: human ... HRH1(3269)

Descrição

Descrição geral

Clemastine fumarate is used to treat multiple sclerosis,[1] sneezing and rhinorrhea linked to common cold.[2] It stimulates oligodendrocyte progenitor cell (OPC) differentiation and myelination.[1]

Aplicação

Clemastine fumarate salt has been used as a stimulator of rodent oligodendrocyte generation and myelination in vitro and in vivo.[3]

Ações bioquímicas/fisiológicas

Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic that also has antipruritic activity.

Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic.

Características e benefícios

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable