SML0389

PF-514273

≥98% (HPLC)

• Sinônimo(s): 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one
• Fórmula empírica (Notação de Hill): C₂₁H₁₇Cl₂F₂N₃O₂
• Número CAS: 851728-60-4
• Peso molecular: 452.28
• Número MDL: MFCD12032112
• Código UNSPSC: 12352202
• ID de substância PubChem: 329825387
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to beige
• solubilidade: DMSO: >5 mg/mL (warmed)
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: CC(F)(F)CN1CCOc2c(nn(-c3ccccc3Cl)c2-c4ccc(Cl)cc4)C1=O
• InChI: 1S/C21H17Cl2F2N3O2/c1-21(24,25)12-27-10-11-30-19-17(20(27)29)26-28(16-5-3-2-4-15(16)23)18(19)13-6-8-14(22)9-7-13/h2-9H,10-12H2,1H3
• chave InChI: FJMQJSUOOGOWBD-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

PF-514273 is a highly selective CB1 antagonist.

PF-514273 is a highly selective CB1 antagonist. The Ki for binding to CB1 and CB2 receptors is 1 nM and 10 mM, respectively. PF-514273 inhibits food intake and weight gain in rodents.

Características e benefícios

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable