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SML0359

Sigma-Aldrich

Norgestimate

≥97% (HPLC)

Sinônimo(s):

(17α)-17-(Acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one 3-oxime, Dexnorgestrel acetime

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About This Item

Fórmula empírica (Notação de Hill):
C23H31NO3
Número CAS:
35189-28-7
Peso molecular:
369.50
Número MDL:
MFCD00867874
Código UNSPSC:
51111800
ID de substância PubChem:
329825361
NACRES:
NA.77

Ensaio

≥97% (HPLC)

forma

powder

cor

white to beige

solubilidade

DMSO: 5 mg/mL (clear solution)

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CC[C@]12CC[C@H]3[C@@H](CCC4=C\C(CC[C@H]34)=N\O)[C@@H]1CC[C@@]2(OC(C)=O)C#C

InChI

1S/C23H31NO3/c1-4-22-12-10-19-18-9-7-17(24-26)14-16(18)6-8-20(19)21(22)11-13-23(22,5-2)27-15(3)25/h2,14,18-21,26H,4,6-13H2,1,3H3/b24-17+/t18-,19+,20+,21-,22-,23-/m0/s1

chave InChI

KIQQMECNKUGGKA-NMYWJIRASA-N

Informações sobre genes

human ... PGR(5241)

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Ações bioquímicas/fisiológicas

Norgestimate is a synthetic progestin used in combination with estrogens as a contraceptive.

Características e benefícios

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palavra indicadora

Warning

Frases de perigo

H302,H315,H319,H361fd

Classificações de perigo

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Visite a Biblioteca de Documentos

Jason D Vescovi et al.
Contraception, 77(2), 97-104 (2008-01-30)
We examined the response of bone turnover markers and indices of energy status after 2 weeks of oral contraceptive (OC) therapy in premenopausal women with exercise-associated menstrual disturbances (EAMD). Six women with EAMD received one 28-day cycle of a triphasic
Susan Jick et al.
Contraception, 76(1), 4-7 (2007-06-26)
In 2006, we published a study that indicated that the new transdermal contraceptive patch containing ethinyl estradiol (EE) and the progestin norelgestromin did not increase the risk for venous thromboembolism (VTE) compared to oral contraceptive containing norgestimate and 35 microg
Matt S Anderson et al.
British journal of clinical pharmacology, 71(4), 616-620 (2011-03-15)
Oral contraceptives such as norgestimate-ethinyl estradiol (Ortho Tri-Cyclen®) are commonly prescribed in the HIV-infected patient population. A placebo-controlled, randomized, two-period crossover study in healthy HIV-seronegative subjects was conducted to assess the effect of raltegravir on the pharmacokinetics of the estrogen
Teri Greco et al.
Contraception, 76(1), 8-17 (2007-06-26)
This study compared two oral contraceptives (OCs) with the same triphasic regimen of progestin (norgestimate 0.18, 0.215 and 0.25 mg) but differing doses of ethinyl estradiol (EE) - 25 and 35 microg EE - in their effects on androgens, mood
Ronald T Burkman et al.
Contraception, 79(6), 424-427 (2009-05-16)
This analysis investigated the association of oral contraceptive efficacy with body weight and body mass index (BMI) for hypothesis-generating purposes. Data were from a randomized, parallel-group trial of 180/215/250 mcg of norgestimate (NGM)/25 mcg of ethinyl estradiol (EE) (given to
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