SML0222

TVP1022

≥98% (HPLC)

• Sinônimo(s): (1S)-2,3-Dihydro-N-2-propyn-1-yl-1H-inden-1-amine, (S)-Rasagiline, S-(-)-N-Propargyl-1-aminoindan
• Fórmula empírica (Notação de Hill): C₁₂H₁₃N
• Número CAS: 185517-74-2
• Peso molecular: 171.24
• Número MDL: MFCD09029306
• Código UNSPSC: 12352200
• ID de substância PubChem: 329825241
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: (Powder, Film or Oil)
• solubilidade: DMSO: ≥15 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: C#CCN[C@H]1CCc2ccccc12
• InChI: 1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m0/s1
• chave InChI: RUOKEQAAGRXIBM-LBPRGKRZSA-N

Descrição

Ações bioquímicas/fisiológicas

TVP1022 is an S-isomer of rasagiline, a PKC Pathway activator and neuroprotective and cytoprotective

TVP1022, the S-isomer of rasagiline, an anti-Parkinson drug, appears to have the same neuroprotective activity as the R-isomer, but is 1000-fold less active as an MAO-B inhibitor. TVP1022, a neuroprotective and cytoprotective molecule, is also cardioprotective in rat models. Its activity is believed to involve stabilization of mitochondrial membrane potential, induction of Bcl-2 and activation of the PKC signalling pathway, enhancing the phosphorylation of protein kinase C and glycogen synthase kinase-3β.

Informações de segurança

• Pictogramas: GHS07,GHS09
• Palavra indicadora: Warning
• Frases de perigo: H302,H400
• Declarações de precaução: P273 - P301 + P312 + P330
• Classificações de perigo: Acute Tox. 4 Oral - Aquatic Acute 1
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable