SMB00314

Coptisine Chloride

≥98% (HPLC)

• Sinônimo(s): Coptisine chloride, Bis(methylenedioxy)protoberberine chloride, Coptisin Chloride
• Fórmula empírica (Notação de Hill): C₁₉H₁₄ClNO₄
• Número CAS: 6020-18-4
• Peso molecular: 355.77
• Número MDL: MFCD00016676
• Código UNSPSC: 12352205
• ID de substância PubChem: 329824946
• NACRES: NA.25

Propriedades

• Ensaio: ≥98% (HPLC)
• forma: powder
• aplicação(ões): metabolomics; vitamins, nutraceuticals, and natural products
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: C1(OCO2)=C2C=C(CC[N+]3=C4C=C5C(C(OCO6)=C6C=C5)=C3)C4=C1.[Cl-]
• InChI: 1S/C19H14NO4.ClH/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14;/h1-2,5-8H,3-4,9-10H2;1H/q+1;/p-1
• chave InChI: LUXPUVKJHVUJAV-UHFFFAOYSA-M

Descrição

Descrição geral

Coptisine chloride is a cytotoxic isoquinoline alkaloid. It is the major bioactive compound of Coptis rhizome, and can also be found in different plants such as Chelidonium majus, Enantia chlorantha. Coptisine is related to berberine and has a similar structure to that of Jatrorrhizine.

Aplicação

Coptisine Chloride has been used to study its binding interactions with single-stranded poly(A) using different absorbance and thermal melting spectroscopic experiments. It may have been used as a standard to analyze Chelidonium majus L. extracted compounds using UV/VIS absorption spectroscopy.

Ações bioquímicas/fisiológicas

Coptisine Chloride is a potent anti-malarial compound, which also exerts anti-cancer and anti-diabetic properties. It elicits protective effects on gastric mucus membrane and is used as a traditional medicine against gastroenteric diseases. Coptisine chloride also displays anti-microbial activities.It has been analyzed as a cytotoxic agent in hepatoma and leukemic cells and is reported to block cell cycle progression.

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H300 + H330
• Declarações de precaução: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233
• Classificações de perigo: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable