Ruscogenin is a major steroidal saponin found in the root of Ophiopogon japonicus. It was first isolated from Ruscus aculeatus.
Aplicação
Ruscogenin has been used to study its therapeutic effects on Crohn′s disease (CD)-like colitis both in vitro and in vivo studies.
Ações bioquímicas/fisiológicas
Ruscogenin is a well-known compound for down-regulating nuclear factor kappa B (NF-κB), intercellular adhesion molecule-1 (ICAM-1), tissue factor (TF), inducible NO synthase (iNOS), and modulating inflammatory pathways. It displays anti-inflammatory properties by inhibiting lipopolysaccharide (LPS)-induced acute lung injury (ALI), and improving diabetic nephropathy in in vivo studies. Ruscogenin also exerts neuroprotective properties and protects the brain against ischemic injury in mouse model. It elicits anti-tumor properties by inducing ferroptosis in pancreatic cancer cells in both in vitro and in vivo studies.
Pancreatic cancer is characterized by aggressive and highly metastatic phenotypes. This disease exhibits a poor patient prognosis and is considered a challenge due to the limited treatment options encountered in clinical practice. Previous studies have shown that ruscogenin, a saponin
Oxidative medicine and cellular longevity, 2022, 4877275-4877275 (2022-03-22)
Interaction of intestinal barrier dysfunction and intestinal inflammation promotes the progression of Crohn's disease (CD). A more recent study has suggested that ruscogenins (RUS) can exert anti-inflammatory effects through activation of the Nrf2/NQO1 pathway. The current study is aimed at
The authors present an account of the therapeutic results with small doses of cytosine arabinoside--20 mg/m2/day--in 56 patients where in almost 10% of the patients long-term "complete" remission was achieved and in 22% partial remission. When very small doses were
World journal of surgery, 16(2), 214-221 (1992-03-01)
One of the most difficult decisions in the management of patients with melanoma remains whether or not to dissect electively the regional lymph nodes of patients with high risk primary tumors. There is abundant evidence that a proportion of such
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