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S8534

Sigma-Aldrich

Sarsasapogenin

≥98%

Sinônimo(s):

(25S)-Spirostan-3β-ol, Parigenin

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About This Item

Fórmula empírica (Notação de Hill):
C27H44O3
Número CAS:
126-19-2
Peso molecular:
416.64
Número CE:
204-776-3
Número MDL:
MFCD00270414
Código UNSPSC:
12352200
ID de substância PubChem:
24899798
NACRES:
NA.25
Preço e disponibilidade não estão disponíveis no momento.

Ensaio

≥98%

aplicação(ões)

metabolomics
vitamins, nutraceuticals, and natural products

cadeia de caracteres SMILES

C[C@H]1CC[C@@]2(OC1)O[C@H]3C[C@H]4[C@@H]5CC[C@@H]6C[C@@H](O)CC[C@]6(C)[C@H]5CC[C@]4(C)[C@H]3[C@@H]2C

InChI

1S/C27H44O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h16-24,28H,5-15H2,1-4H3/t16-,17-,18+,19-,20+,21-,22-,23-,24-,25-,26-,27+/m0/s1

chave InChI

GMBQZIIUCVWOCD-WWASVFFGSA-N

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Categorias relacionadas

Descrição geral

Sarsasapogenin also known as Sarsagenin or Parigenin, is a steroidal saponin and is the main constituent of Anemarrhena asphodeloides Bunge.[1]

Aplicação

Sarsasapogenin has been used as a synthetic saponin treatment to U-2 OS cells to test its effects in reducing osteosarcoma cell viability and down-regulating YAP and TAZ proteins.[2]

Ações bioquímicas/fisiológicas

Sarsasapogenin is a well-known multi-target directed ligand (MTDL) for Alzheimer′s disease.[3] It elicits anti-inflammatory, antioxidant, anti-arthritis, anti-asthma, anti-amyloidogenic, neuroprotective, anti-depressant, and anti-cancer properties.[1][3][4] SAR also improves learning and memory ability, loss of neurons in type-1 diabetic rats and protects against diabetic encephalopathy.[1] It is also a therapeutic target for treating ulcerative colitis (UC).[4] SAR as an anti-inflammatory agent improves insulin resistance and adipose tissue inflammation in high-fat diet (HFD)-fed mice.[5]

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
0000431322
0000431322
0000366482
0000366701
0000366481

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Protodioscin phyproof® Reference Substance

PHL80522

Protodioscin

Ruscogenin ≥98% (HPLC)

Sigma-Aldrich

SMB00295

Ruscogenin

vibrant-m

Y0001564

Quillaia saponin assay

vibrant-m

Y0001537

Purified quillaia saponins

Akebia saponin D ≥98% (HPLC)

Sigma-Aldrich

SML1822

Akebia saponin D

Yan-Yan Yu et al.
Acta pharmacologica Sinica, 42(2), 272-281 (2020-07-24)
Insulin resistance is a major cause of type 2 diabetes and metabolic syndrome. Macrophage infiltration into obese adipose tissue promotes inflammatory responses that contribute to the pathogenesis of insulin resistance. Suppression of adipose tissue inflammatory responses is postulated to increase
Priya Kashyap et al.
Steroids, 153, 108529-108529 (2019-11-02)
Alzheimer's disease (AD) is multi-factorial disorder characterized by impaired memory and cognition deficit. AD is characterized by impaired cholinergic transmission, extracellular amyloid beta deposits, neurofibrillary tangles and oxidative stress. A multi-target directed ligand (MTDL) approach is required to devise a
Maria Ferraiuolo et al.
Cancer letters, 433, 18-32 (2018-06-23)
Osteosarcoma (OS) is the most aggressive type of primary solid tumor that develops in bone. Whilst conventional chemotherapy can improve survival rates, the outcome for patients with metastatic or recurrent OS remains poor, so novel treatment agents and strategies are
Deepa S Mandlik et al.
Immunopharmacology and immunotoxicology, 43(5), 571-583 (2021-08-03)
Ulcerative colitis (UC) is a chronic inflammatory bowel condition considered by oxido-nitrosative stress and the release of pro-inflammatory cytokines that affects the mucosal lining of the colon. Sarsasapogenin (SG), as an active component, has been found in many plants, and
Yu-Meng Zhang et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 91, 153686-153686 (2021-08-02)
A crosstalk exists between diabetes and Alzheimer's disease (AD), and diabetic encephalopathy displays AD-like disorders. Sarsasapogenin (Sar) has strong anti-inflammatory efficacy, showing neuroprotection and memory-enhancement effects. This study aims to verify the ameliorative effects of Sar on diabetic encephalopathy in
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