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SCP0169

Sigma-Aldrich

HIV-1 Tat Peptide

≥95% (HPLC), lyophilized powder

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About This Item

Fórmula empírica (Notação de Hill):
C65H124N34O13
Peso molecular:
1589.90
Código UNSPSC:
12352202
NACRES:
NA.32

product name

HIV-TAT (48-57),

Ensaio

≥95% (HPLC)

forma

lyophilized

composição

Peptide Content, ≥55%

condição de armazenamento

protect from light

temperatura de armazenamento

−20°C

Amino Acid Sequence

Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-NH2

Descrição geral

Human immunodeficiency virus (HIV)-transactivator of transcription (Tat), a regulatory protein is coded by the Tat gene of HIV-1. Tat is made up of two exons, highly conserved regions, and subtype-specific regions.

Ações bioquímicas/fisiológicas

Human immunodeficiency virus (HIV)-transactivator of transcription (Tat) participates in the pathogenesis of HIV-related complications. Tat protein is also involved in HIV-related cardiac dysfunction. HIV-TAT (48-57) is used to facilitate the internalization of synthetic peptides.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Yanan Jiang et al.
Journal of translational medicine, 16(1), 121-121 (2018-05-10)
The human immunodeficiency virus (HIV) is a major global public health issue. HIV-related cardiovascular disease remains a leading cause of morbidity and mortality in HIV positive patients. HIV Tat is a regulatory protein encoded by tat gene of HIV-1, which
S-M Lee et al.
Clinical and experimental immunology, 161(3), 504-511 (2010-07-22)
The immune receptor expressed on myeloid cells 1 (IREM-1) has been known to regulate the activities of myeloid cells through its immunoreceptor tyrosine-based inhibition motifs (ITIMs) in its intracellular region. In order to investigate its effect on macrophage activation, a
S-M Lee et al.
Clinical and experimental immunology, 167(3), 438-446 (2012-02-01)
The immune receptor expressed on myeloid cells 1 (IREM-1/CD300F) has been shown to inhibit various inflammatory processes in myeloid cells, such as macrophages and mast cells. IREM-1 exerts its inhibitory effect through its intracellular immunoreceptor tyrosine-based inhibition motifs (ITIMs). In

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