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Key Documents

SAB4503874

Sigma-Aldrich

Anti-phospho-GR (pSer226) antibody produced in rabbit

affinity isolated antibody

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

antigen 85 kDa

reatividade de espécies

mouse, rat, human

concentração

~1 mg/mL

técnica(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

nº de adesão NCBI

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

phosphorylation (pSer226)

Informações sobre genes

human ... GCR(2908)

Categorias relacionadas

Descrição geral

Glucocorticoid receptor (GR) gene/NR3C1 (nuclear receptor subfamily 3 group C member 1) is located on human chromosome 5q31. It belongs to the steroid receptor superfamily that has ligand-activated nuclear transcription factors.

Imunogênio

The antiserum was produced against synthesized peptide derived from human GR around the phosphorylation site of Ser226.

Immunogen Range: 201-250

Ações bioquímicas/fisiológicas

The glucocorticoid receptor (GR) gene/(NR3C1) is associated with asthma. It is required for glucose homeostasis and has been associated with hyperinsulinemia and increased fat deposition. GR also regulates cell differentiation, nervous and immune system functions.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

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Multiple promoters exist in the human GR gene, one of which is activated by glucocorticoids
Breslin MB, et al.
Molecular Endocrinology, 15(8), 1381-1395 (2001)
Glucocorticoid receptor polymorphism in obesity and glucose homeostasis
Majer-Lobodzinska A and Adamiec-Mroczek J
Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University, 26(1), 143-148 (2017)
Identification of polymorphisms in the human glucocorticoid receptor gene (NR3C1) in a multi-racial asthma case and control screening panel
Hawkins GA, et al.
Dna Sequence, 15(3), 167-173 (2004)
Structure of the glucocorticoid receptor (NR3C1) gene 5' untranslated region: identification, and tissue distribution of multiple new human exon 1
Turner JD and Muller CP
Journal of Molecular Endocrinology, 35(2), 283-292 (2005)
Alexander S Häusl et al.
Molecular psychiatry, 26(7), 3060-3076 (2021-03-03)
Disturbed activation or regulation of the stress response through the hypothalamic-pituitary-adrenal (HPA) axis is a fundamental component of multiple stress-related diseases, including psychiatric, metabolic, and immune disorders. The FK506 binding protein 51 (FKBP5) is a negative regulator of the glucocorticoid

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