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SAB4503300

Sigma-Aldrich

Anti-TAS1R3 antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

Sweet taste receptor T1R3

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

antigen 93 kDa

reatividade de espécies

human

concentração

~1 mg/mL

técnica(s)

ELISA: 1:10000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

nº de adesão NCBI

Q7RTX0

nº de adesão UniProt

Q7RTX0

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... TAS1R3(83756)

Descrição geral

Taste receptor family 1 member 3 (TAS1R3) gene encodes for sweet taste receptor T1R3 protein. T1R3 protein belongs to the family of 3 subtypes of G-protein coupled receptors (GPCRs). This protein is localized in the taste bud cells of the oral cavity. The TAS1R3 gene is mapped on the human chromosome at 1p36.33.

Imunogênio

The antiserum was produced against synthesized peptide derived from human TAS1R3.

Immunogen Range: 326-375

Aplicação

Anti-TAS1R3 antibody produced in rabbit has been used in immunohistochemistry and immunocytochemistry.

Ações bioquímicas/fisiológicas

Sweet taste receptor T1R3 protein plays a role in membrane glucose sensing and regulates glucose homeostasis in endocrine cells..

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac.
Max, et al.
Nature Genetics, 28, 58-63 (2019)
Mariam Raliou et al.
Neuroscience letters, 451(3), 217-221 (2009-01-17)
Monosodium glutamate as well as metabotropic and ionotropic glutamate receptor agonists have been reported to be perceived as umami by humans. In spite of the fact that Tas1R1-Tas1R3 has been shown to mediate most of the glutamate taste sensation in
Marco Tizzano et al.
Chemical senses, 40(9), 655-660 (2015-09-25)
The morphology of the vallate papillae from postmortem human samples was investigated with immunohistochemistry. Microscopically, taste buds were present along the inner wall of the papilla, and in some cases in the outer wall as well. The typical taste cell
Vladimir O Murovets et al.
PloS one, 10(6), e0130997-e0130997 (2015-06-25)
The G-protein-coupled sweet taste receptor dimer T1R2/T1R3 is expressed in taste bud cells in the oral cavity. In recent years, its involvement in membrane glucose sensing was discovered in endocrine cells regulating glucose homeostasis. We investigated importance of extraorally expressed

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