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SAB4500989

Sigma-Aldrich

Anti-FOLR1 antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

FR-α, Folate receptor, Folate receptor α, Folate receptor 1, adult

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About This Item

Número MDL:
MFCD02262889
Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

antigen 29 kDa

reatividade de espécies

rat, mouse, human

concentração

~1 mg/mL

técnica(s)

ELISA: 1:1000
western blot: 1:500-1:1000

nº de adesão NCBI

P15328

nº de adesão UniProt

P15328

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... FOLR1(2348)

Categorias relacionadas

Descrição geral

The folate receptor 1 (FOLR1) gene encodes for folate receptor α protein, a membrane-bound glycoprotein. The FOLR1 gene is mapped on the human chromosome at 11q13.4. Anti-FOLR1 antibody detects endogenous levels of total FOLR1 protein.

Imunogênio

The antiserum was produced against synthesized peptide derived from human FOLR1.

Immunogen Range: 41-90

Ações bioquímicas/fisiológicas

Folate receptor α protein binds and facilitates the transport of folate into the cells. This protein acts as a therapeutic target as well as a prognostic marker for various kinds of cancers. Upregulation of the FOLR1 gene is associated with ovarian, lung, breast, brain, colorectal, and gastric cancers.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Visite a Biblioteca de Documentos

Michelle R O'Byrne et al.
Birth defects research. Part A, Clinical and molecular teratology, 88(8), 689-694 (2010-08-05)
Meningomyelocele (MM) results from lack of closure of the neural tube during embryologic development. Periconceptional folic acid supplementation is a modifier of MM risk in humans, leading toan interest in the folate transport genes as potential candidates for association to
Yuan Yuan et al.
Human pathology, 40(10), 1453-1460 (2009-05-21)
The objective of this study was to analyze the diagnostic and clinical role of the folate receptor-alpha (FOLR1) and folate receptor-gamma (FOLR3) genes in effusion cytology. Expression of the FOLR1 protein product, FR-alpha, was additionally studied. Ninety-one effusions (71 ovarian
Minsung Kim et al.
PloS one, 13(6), e0198347-e0198347 (2018-06-07)
Gastric cancer is a malignancy that has a high mortality rate. Although progress has been made in the treatment of gastric cancer, many patients experience cancer recurrence and metastasis. Folate receptor 1 (FOLR1) is overexpressed on the cell surface in
Correction: Folate receptor-α (FOLR1) expression and function in triple negative tumors.
Brian M Necela et al.
PloS one, 10(4), e0127133-e0127133 (2015-05-01)

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