SAB4300564

Anti-SMAD3 (Ab-208) antibody produced in rabbit

affinity isolated antibody

• Sinônimo(s): Anti-DKFZp586N0721 antibody produced in rabbit, Anti-DKFZp686J10186 antibody produced in rabbit, Anti-HSPC193 antibody produced in rabbit, Anti-HsT17436 antibody produced in rabbit, Anti-SMAD family member 3 antibody produced in rabbit
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: ~52 kDa
• reatividade de espécies: rat, human, mouse
• concentração: 1 mg/mL
• técnica(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200
• Isotipo: IgG
• sequência de imunogênio: (N-L-S-P-N)
• nº de adesão NCBI: NP_001138574.1
• nº de adesão UniProt: P84022
• aplicação(ões): research pathology
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... SMAD3(4088)

Descrição

Descrição geral

SMAD3 (SMAD family member 3) is located on chromosome 15q22.

Imunogênio

Peptide sequence around aa. 206-210 (N-L-S-P-N), according to the protein SMAD3.

Ações bioquímicas/fisiológicas

SMAD3 (SMAD family member 3) plays a major role in the intracellular signaling of transforming growth factorβ(TGFβ). Reducing the phosphorylation level of Smad3 helps autophagy to control endothelial-mesenchymal transition. In arterial smooth muscle cells, suppression of SMAD3 results in elevating cell viability.

Características e benefícios

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Descrição-alvo

Smad3 encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable