SAB4200784
Anti-Cellular Fibronectin antibody, Mouse monoclonal
clone FN-3E2, hybridoma cell culture supernatant
Sinônimo(s):
Anti-CIG, Anti-Cold-insoluble globulin, Anti-FN
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100 μL
R$ 2.876,00
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100 μL
R$ 2.876,00
About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Produtos recomendados
fonte biológica
mouse
Nível de qualidade
forma do anticorpo
culture supernatant
tipo de produto de anticorpo
primary antibodies
clone
FN-3E2, monoclonal
Formulário
buffered aqueous solution
peso molecular
~220-260 kDa
reatividade de espécies
chicken, rat, human, mouse
técnica(s)
immunoblotting: suitable
immunofluorescence: 1:2,000-1:4,000 using human foreskin fibroblast Hs68 cells
immunohistochemistry: suitable
Isotipo
IgM
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... FN1(2335)
Categorias relacionadas
Descrição geral
Anti-Cellular Fibronectin antibody, Mouse monoclonal (mouse IgM isotype) is derived from the FN-3E2 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from mice immunized with the antigens released in culture from a breast cancer cell line. Fibronectin (FN), also known as cold-insoluble globulin (CIG), is an extracellular matrix multi-domain glycoprotein composed of two nearly identical disulphide bound polypeptides. Fibronectin 1 is a glycoprotein, that is coded by FN1 gene. It is expressed in the plasma and at the cell surface. It is mapped to human chromosome 2q35. Cellular fibronectin is produced by various cell types, including fibroblasts, endothelial cells, chondrocytes, synovial cells, and myocytes.
Imunogênio
Antigens released in culture from a breast cancer cell line
Aplicação
Anti-Cellular Fibronectin antibody, Mouse monoclonal has been used in:
- immunoblotting
- immunofluorescence
- immunohistochemistry
Anti-cellular Fibronectin antibody, mouse monocloneal has been used in various immunochemical techniques including immunoblotting (220-260 kDa), immunofluorescence, and immunohistochemistry.
Ações bioquímicas/fisiológicas
Fibronectin participates in cell adhesion, growth, migration, wound healing, blood coagulation and metastasis. Mutations in FN1 results in glomerulopathy. It plays an important role in cell attachment and spreading, control of cell cytoskeleton, morphology and differentiation. FN1 is also involved in extracellular matrix formation, haemostasis and thrombosis. It is a ubiquitous and essential component of the extracellular matrix (ECM) and plays a vital role in tissue repair mechanism.
forma física
The product is supplied as a culture supernatant solution containing 15 mM sodium azide as a preservative. The product contains fetal calf serum.
Outras notas
This product is for R&D use only, not for drug, household, or other uses.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator.
Moser TL, et al.
The Journal of Biological Chemistry, 268(25), 18917-18923 (1993)
Receptors for cold-insoluble globulin (plasma fibronectin) on human monocytes.
Bevilacqua MP, et al.
The Journal of Experimental Medicine, 153(1), 42-60 (1981)
Paulina Escandon et al.
International journal of molecular sciences, 23(8) (2022-04-24)
Salivary exosomes have demonstrated vast therapeutic and diagnostic potential in numerous diseases. This study pioneers previously unexplored roles of SE in the context of corneal wound healing by utilizing primary corneal stromal cells from healthy (HCFs), type I diabetes mellitus
Plasma and cellular fibronectin: distinct and independent functions during tissue repair
To WS, et al.
Fibrogenesis & Tissue Repair, 4(1), 21-21 (2011)
Somshuvra Bhattacharya et al.
Frontiers in bioengineering and biotechnology, 8, 1040-1040 (2020-10-06)
Oxygen deprivation within tumors is one of the most prevalent causes of resilient cancer cell survival and increased immune evasion in breast cancer (BCa). Current in vitro models do not adequately mimic physiological oxygen levels relevant to breast tissue and
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